Hypercytokinemia: Increased or decreased innate immunity? [PDF]
, 2008 The adipose tissue is an active endocrine organ which secretes proinflammatory cytokines and chemokines resulting into raised serum levels. Hypercytokinemia has been interpreted as raised level of innate immunity and its evolution is interpreted as a ...
Milind Watve +2 more
core +4 more sources
Exploiting innate immunity for cancer immunotherapy
Molecular Cancer, 2023 Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint ...
Ming Yi +7 more
semanticscholar +1 more source
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Nature Immunology, 2022 Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent antibody
Chunfeng Li +23 more
semanticscholar +1 more source
Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection
Cell Death and Disease, 2023 Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin ...
Sarah Rosli +7 more
doaj +1 more source
'Towards a Conceptual Framework for Innate Immunity' [PDF]
, 2005 Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
core +5 more sources
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
EMBO Molecular Medicine, 2022 Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot +16 more
doaj +1 more source
Early Interferon-γ Production in Human Lymphocyte Subsets in Response to Nontyphoidal Salmonella Demonstrates Inherent Capacity in Innate Cells [PDF]
, 2010 Background Nontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Anna E. Seeley +5 more
core +15 more sources
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Journal of Inflammation, 2023 Background Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce
Kristian Barry +4 more
doaj +1 more source
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
doaj +1 more source
Trained Immunity: Reprogramming Innate Immunity in Health and Disease.
Annual Review of Immunology, 2021 Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has shifted: Cells of the innate immune system appear to be able to gain memory characteristics ...
S. Bekkering +4 more
semanticscholar +1 more source