Results 1 to 10 of about 730,043 (275)
Otolaryngologic Clinics of North America, 2010 Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS).
Ooi, Eng Hooi +3 more
+9 more sources
Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection
Cell Death and Disease, 2023 Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin ...
Sarah Rosli +7 more
doaj +1 more source
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
EMBO Molecular Medicine, 2022 Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot +16 more
doaj +1 more source
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Journal of Inflammation, 2023 Background Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce
Kristian Barry +4 more
doaj +1 more source
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
doaj +1 more source
Imaging innate immunity* [PDF]
Immunological Reviews, 2021 AbstractInnate immunity is the first line of defense against infectious intruders and also plays a major role in the development of sterile inflammation. Direct microscopic imaging of the involved immune cells, especially neutrophil granulocytes, monocytes, and macrophages, has been performed since more than 150 years, and we still obtain novel ...
Anika Grüneboom +5 more
openaire +2 more sources
Journal of Extracellular Vesicles, 2021 Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue.
Christina F. Budden +5 more
doaj +1 more source
Nature Communications, 2023 The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined,
L. S. Tran +26 more
doaj +1 more source
Scientific Reports, 2021 Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection.
Pragya Prakash +2 more
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ATP-binding and hydrolysis of human NLRP3
Communications Biology, 2022 Analysis of the inflammasome-forming protein NLRP3 provides insights into the function of conserved residues in the ATP-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activation.
Rebecca Brinkschulte +10 more
doaj +1 more source