Results 101 to 110 of about 2,416,042 (300)

Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2018
After the recognition of the essential role of the immune system in the progression of type 2 diabetes mellitus, more studies are focused on the effects produced by the abnormal differentiation of components of the immune system.
Tong Zhou, Zheng Hu, Shuo Yang, Lin Sun, Zhenxiang Yu, Guixia Wang   +5 more
semanticscholar   +1 more source

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. [PDF]

, 2018
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely ...
A Marusyk, AD Rouillard, Amir Reza Aref, AN Hata, Anika Elise Adeni, AR Aref, Brandon Piel, C Henke, Camilla Laulund Christensen, CD Carey, Christine Anne Lydon, CL Christensen, Cloud Peter Paweletz, D Gao, D Hanahan, D Miao, D Pan, D Peng, D Roulois, DA Barbie, DA Rhodes, David Allen Barbie, Debattama Rai. Sen, Diana Miao, DJ Konieczkowski, DP Tabassum, DR Sen, EB Chuong, Evisa Gjini, Ewa Sicinska, F Perocchi, G Bindea, Gao Zhang, Hideki Terai, Hideo Baba, Hideo Watanabe, I Canadas, I Tirosh, Israel Cañadas, J Barretina, J Calbo, J Chen, Jacob Sands, JG Doench, Jong Wook Kim, JT Poirier, JW Kim, KA Hoadley, KB Chiappinelli, Kwok Kin Wong, Lynnette Marie Sholl, Marco Campisi, Masayuki Watanabe, Meenhard Herlyn, MR Junttila, NE Sanjana, O Shalem, Pablo Tamayo, Ravindra Uppaluri, Rohit Thummalapalli, RT Manguso, Russell William Jenkins, RW Jenkins, Scott Rodig, Shohei Koyama, Shunsuke Kitajima, Thanh Uyen Barbie, Tian Tian, Timothy Hagan, Tran Thai, X Wu, Y Qiao, Yanan Kuang, Yanxi Zhang, Yu Imamura, Zhi Wei   +75 more
core   +1 more source

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. [PDF]

, 2019
Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases.
Cohen Katsenelson, Ksenya, Glass, Christopher K, Kawashima, Agnieszka T, Lordén, Gema, Newton, Alexandra C, Nizet, Victor, Stender, Joshua D, Uchiyama, Satoshi   +7 more
core   +1 more source

Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster [PDF]

, 2010
Much of our knowledge on hematopoiesis, hematopoietic compartments, hematopoietic cell lineages and immunity has been derived from studies on the vertebrate immune system.
Brehélin, Crozatier, Ferenc Jankovics, Goto, Gábor Csordás, Hedengren, Holz, Honti, Hultmark, István Andó, Ito, Jankovics, Kimbrell, Krzemień, Kurucz, Kurucz, Kurucz, Lanot, Lebestky, Mandal, Márkus, Nappi, Olofsson, Rizki, Rizki, Russo, Róbert Márkus, Shrestha, Sorrentino, Stramer, Tokusumi, Viktor Honti, Zettervall, Éva Kurucz   +33 more
core   +1 more source

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

Frontiers in Immunology
Lipopolysaccharide (LPS), also known as an endotoxin, is derived from Gram-negative bacteria. The intravenous administration of LPS induces an inflammatory response and causes systemic inflammation, such as cytokine storm.
Gen-Ichiro Soma, Gen-Ichiro Soma, Masataka Oda, Vindy Tjendana Tjhin, Chie Kohchi, Hiroyuki Inagawa, Hiroyuki Inagawa   +6 more
doaj   +1 more source

Interferon Lambda Genetics and Biology in Regulation of Viral Control

Frontiers in Immunology, 2017
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
doaj   +1 more source

Microbiome-gut-brain axis and toll-like receptors in parkinson\u2019s disease [PDF]

, 2018
Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy, which involves all districts of the brain-gut axis, including the central, autonomic and enteric nervous systems.
Caputi, Valentina, Giron, Maria Cecilia
core   +2 more sources

Encapsulation and Melanization Are Not Correlated to Successful Immune Defense Against Parasitoid Wasps in Drosophila melanogaster

Cells
Parasitoid elimination in Drosophila melanogaster involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a potential
Lilla B. Magyar, István Andó, Gyöngyi Cinege   +2 more
doaj   +1 more source

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

EMBO Molecular Medicine, 2019
Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an obligate requirement by oncogenic KRAS for the ADAM17 protease in LAC.
Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins   +23 more
doaj   +1 more source

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

International Journal of Molecular Sciences, 2017
Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their ...
D. Hirayama, T. Iida, H. Nakase
semanticscholar   +1 more source