Results 51 to 60 of about 287,222 (242)

Mechanisms of activation of innate-like intraepithelial T lymphocytes [PDF]

, 2020
Intraepithelial T lymphocytes (T-IEL) contain subsets of innate-like T cells that evoke innate and adaptive immune responses to provide rapid protection at epithelial barrier sites. In the intestine, T-IEL express variable T cell antigen receptors (TCR),
Vandereyken, Maud, Swamy, Mahima; id_orcid, James, Olivia   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

PLoS ONE, 2015
Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis.
James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Dynamic Changes in Uterine NK Cell Subset Frequency and Function Over the Menstrual Cycle and Pregnancy

Frontiers in Immunology, 2022
Uterine natural killer cells (uNK) play an important role in promoting successful pregnancy by regulating trophoblast invasion and spiral artery remodelling in the first trimester.
Emily M. Whettlock, Ee Von Woon, Antonia O. Cuff, Brendan Browne, Mark R. Johnson, Victoria Male   +5 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Expression of genes related to anti-inflammatory pathways are modified among farmers' children [PDF]

, 2014
The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in
Loeliger, Susanne, Roduit, Caroline; https://orcid.org/, van Hage, Marianne, Göran Pershagen, Sennhauser, Felix, Lauener, Roger P., Remo Frei, Marianne van Hage (91132), IRAS RATIA2, Felix Sennhauser, Susanne Loeliger (254440), von Mutius, Erika, Erika von Mutius (105805), Caroline Roduit (254441), Gert Doekes (397763), as part of the Parsifal study team,, Christian Bieli (531936), Waser, Marco, Cezmi A Akdis, Christian Bieli, Mutius, Erika von, Annika Scheynius, Roduit, Caroline, Riedler, Josef, Göran Pershagen (147977), LS IRAS EEPI GRA (Gezh.risico-analyse), Braun-Fahrländer, Charlotte, Remo Frei (254425), Roger P. Lauener (254451), Caroline Roduit, Akdis, Cezmi A, Risk Assessment of Toxic and Immunomodulatory Agents, Lauener, Roger P, Cezmi A. Akdis (187641), Akdis, Cezmi A., Marco Waser, Pershagen, Göran, Erika von Mutius, Doekes, Gert, Gert Doekes, Felix Sennhauser (531938), Josef Riedler, Susanne Loeliger, Charlotte Braun-Fahrländer, Hage, Marianne van, Frei, Remo, Scheynius, Annika, as part of the PARSIFAL study team, Roger P Lauener, Annika Scheynius (31954), Josef Riedler (194501), Charlotte Braun-Fahrländer (18248), Bieli, Christian, Marianne van Hage, Marco Waser (531937)   +54 more
core   +1 more source

Specialized Roles of Human Natural Killer Cell Subsets in Kidney Transplant Rejection

Frontiers in Immunology, 2019
Background: Human natural killer (NK) cells are key functional players in kidney transplant rejection. However, the respective contributions of the two functionally distinct human NK cell subsets (CD56bright cytokine-producing vs.
Katrina Kildey, Katrina Kildey, Ross S. Francis, Sebastian Hultin, Sebastian Hultin, Sebastian Hultin, Michelle Harfield, Kurt Giuliani, Kurt Giuliani, Kurt Giuliani, Becker M. P. Law, Becker M. P. Law, Becker M. P. Law, Becker M. P. Law, Xiangju Wang, Xiangju Wang, Emily J. See, George John, Jacobus Ungerer, Ray Wilkinson, Ray Wilkinson, Ray Wilkinson, Ray Wilkinson, Ray Wilkinson, Andrew J. Kassianos, Andrew J. Kassianos, Andrew J. Kassianos, Andrew J. Kassianos, Andrew J. Kassianos, Helen Healy, Helen Healy, Helen Healy   +31 more
doaj   +1 more source