Results 41 to 50 of about 290,827 (234)
Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells
Frontiers in Oncology, 2023 Endothelial cells and immune cells are major regulators of cancer progression and prognosis. Endothelial cell proliferation and angiogenesis are required for providing nutrients and oxygen to the nascent tumor and infiltration of immune cells to the ...
Svenja Ebeling +7 more
doaj +1 more source
Bcl11b drives the birth of ILC2 innate lymphocytes. [PDF]
J Exp Med, 2015 ![Figure][1] Insight from Chao Zhong (left) and Jinfang Zhu (right) Effective immune responses to pathogens require the activation and differentiation of both innate and adaptive lymphocytes, such as innate lymphoid cells (ILCs) and T cells, respectively. ILCs consist of distinct helper-
Zhong C, Zhu J.
europepmc +4 more sources
The Regulation of Inflammation by Innate and Adaptive Lymphocytes
Journal of Immunology Research, 2018 Inflammation plays an essential role in the control of pathogens and in shaping the ensuing adaptive immune responses. Traditionally, innate immunity has been described as a rapid response triggered through generic and nonspecific means that by definition lacks the ability to remember.
David Alex Cronkite, Tara M. Strutt
openaire +4 more sources
Innate-like T lymphocytes in chronic liver disease
Frontiers in Immunology, 2023 In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis.
Maria Papanastasatou +1 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Aberrant lymphocyte homing could potentially link inflammatory processes in the intestine and the liver, as distinct hepatobiliary diseases frequently develop as extra-intestinal manifestations in inflammatory bowel disease.
Angela Schippers +10 more
doaj +1 more source
The Roles of Liver-Resident Lymphocytes in Liver Diseases
Frontiers in Immunology, 2019 Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and adaptive immunity. In recent years, many studies have shown that multiple types of lymphocytes are resident in the liver, including memory CD8+ T (TRM) cells ...
Yanan Wang, Cai Zhang
doaj +1 more source
Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection
Frontiers in Immunology, 2023 BackgroundIntraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4+ T IELs provide an efficient and a long-
Fatima Hariss +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interactions between the microbiota and innate and innate-like lymphocytes
Journal of Leukocyte Biology, 2017 Abstract The microbiota, which consists of commensal bacteria, fungi, and viruses, limits the colonization of pathogens at barrier tissues and promotes immune homeostasis. The latter is accomplished through the induction and regulation of both innate and adaptive immune responses.
openaire +2 more sources