Results 21 to 30 of about 290,827 (234)
Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection [PDF]
Cell Host and Microbe, 2018 Marcel Wüthrich +2 more
exaly +2 more sources
Cancer Immunotherapy by Blocking Immune Checkpoints on Innate Lymphocytes. [PDF]
Cancers (Basel), 2020 Immune checkpoints refer to a plethora of inhibitory pathways of the immune system that play a crucial role in maintaining self-tolerance and in tuning the duration and amplitude of physiological immune responses to minimize collateral tissue damages. The breakdown of this delicate balance leads to pathological conditions, including cancer.
Pesce S +14 more
europepmc +9 more sources
Innate-like lymphocytes in intestinal infections [PDF]
Current Opinion in Infectious Diseases, 2015 The mechanisms of immunity against intestinal pathogens are not well understood. Innate-like lymphocytes are a group of recently discovered cells that do not fit into either side of the historical innate-adaptive classification. They are enriched in the intestinal mucosa and participate in gut homeostasis and defense against infections.
Michael S, Bennett +2 more
openaire +2 more sources
Innate lymphocyte cells in asthma phenotypes [PDF]
Clinical and Translational Allergy, 2015 AbstractT helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment ...
Ozyigit, Leyla Pur +2 more
openaire +3 more sources
The cGAS-STING Pathway: A Promising Immunotherapy Target
Frontiers in Immunology, 2021 With the continuous development of immunotherapy, researchers have paid more attention to the specific immune regulatory mechanisms of various immune responses in different diseases.
Liang Ou +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Cancer immunotherapy has led to impressive advances in cancer treatment. Unfortunately, in a high percentage of patients is difficult to consistently restore immune responses to eradicate established tumors. It is well accepted that adaptive immune cells,
Rosalia Busà +8 more
doaj +1 more source
Overview of the development, characterization, and function of human types 1, 2, and 3 innate lymphoid cells [PDF]
Einstein (São Paulo)Hematopoiesis is characterized by the differentiation and maturation of multipotent stem cells into hematopoietic cells. Common lymphoid progenitor cells differentiate into B and T lymphocytes; natural killer cells can also originate from common lymphoid
Laiz Cameirão Bento +2 more
doaj +1 more source
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. [PDF]
PLoS ONE, 2014 Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes.
Shannon A Carty +2 more
doaj +1 more source
Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages
Frontiers in Immunology, 2018 Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family
Chun Chou, Ming O. Li
doaj +1 more source
Innate lymphocytes-lineage, localization and timing of differentiation. [PDF]
Cell Mol Immunol, 2019 Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune challenge. While circulating cytotoxic natural killer (NK) cells have been studied for decades, tissue-resident innate lymphoid cells (ILCs) have only been characterized and studied over the past few years.
Kansler ER, Li MO.
europepmc +4 more sources