Results 41 to 50 of about 191,579 (251)

Phenotypic and functional alterations of innate lymphoid cells in hematological malignancies: potential clinical application [PDF]

Exploration of Immunology
Innate lymphoid cells are lymphocytes that are neither T cells nor B cells. They are relatively rare in lymphoid tissues and peripheral blood and are distinguished by their absence of an adaptive antigen receptor.
Mario Di Gioacchino, Antonio Pagana, Giuseppe Mirabile, Loredana della Valle, Fabio Stagno, Sebastiano Gangemi, Alessandro Allegra   +6 more
doaj   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

Plastic fantastic innate lymphoid cells [PDF]

Journal of Experimental Medicine, 2019
In this issue of JEM, Nagasawa et al. (https://doi.org/10.1084/jem.20190490) have undertaken a detailed study of the cell surface phenotype, transcriptional profile, and cytokine secretion of ILC progenitor populations in human peripheral blood and tissues and describe markers that highlight the heterogeneity of these chameleons.
openaire   +4 more sources

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation [PDF]

Cell, 2017
An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated in the duration of intestinal inflammation. Here, we identify a regulatory subpopulation of ILCs (called ILCregs) that exists in the gut and harbors a unique gene identity ...
Shuo, Wang, Pengyan, Xia, Yi, Chen, Yuan, Qu, Zhen, Xiong, Buqing, Ye, Ying, Du, Yong, Tian, Zhinan, Yin, Zhiheng, Xu, Zusen, Fan   +10 more
openaire   +2 more sources

IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells

OncoImmunology
Interleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina, Francesca Romana Mariotti, Enrico Munari, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +7 more
doaj   +1 more source

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source

Tissue localization of natural killer cells dictates surveillance of lung metastasis

Nature Communications
The lung is a common metastatic site for various cancer types. Successful immune surveillance of lung metastasis depends on Natural Killer (NK) cells, but the underlying mechanisms are elusive.
Marijne Vermeer, Colin Sparano, Nicolò Coianiz, Maud Mayoux, Gioana Litscher, André Fonseca, Stanislav Dergun, Caroline Mussak, Lukas Rindlisbacher, Philipp Häne, Laura Ducimetière, Tobias Wertheimer, Burkhard Becher, Lothar C. Dieterich, Sònia Tugues   +14 more
doaj   +1 more source

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

Frontiers in Immunology
Innate immunity is the first line of defense against infections, including the detection and response to SARS-CoV-2. Cells of the innate system are usually activated within hours after pathogen exposure and do not generate conventional immunological ...
Enrico Maggi, Nadine Landolina, Francesca Romana Mariotti, Enrico Munari, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta   +7 more
doaj   +1 more source

Innate Lymphoid Cells in Human Pregnancy

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ...
João Mendes, João Mendes, João Mendes, João Mendes, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Manuel Santos-Rosa, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto   +18 more
doaj   +1 more source

Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency is associated with more severe asthma. Objective: We aimed to assess the immunoregulatory effects of VitD3 food supplementation on asthma manifestation, with
Janina C. Grund, Susanne Krammer, RPh, Zuqin Yang, MSc, Hannah Mitländer, Manfred Rauh, PhD, Sabine Zirlik, MD, Alexander Kiefer, MD, Theodor Zimmermann, MD, Ralf J. Rieker, MD, Carol I. Geppert, MD, Nikolaos G. Papadopoulos, MD, Susetta Finotto, PhD   +11 more
doaj   +1 more source