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Haunting innate immune memories of COVID-19
Cell, 2023In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors
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Molecular mechanisms of innate memory and tolerance to LPS
Journal of Leukocyte Biology, 2016Abstract LPS is a potent trigger of macrophage-mediated inflammation. However, prolonged exposure to LPS induces a state of tolerance that reprograms the inflammatory response, resulting in reduced inflammatory cytokine production in vitro and in vivo.
John J, Seeley, Sankar, Ghosh
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Specific memory within innate immune systems
Trends in Immunology, 2005Research into immune defense has been considerably enriched by the increasing focus on innate immunity. This type of immunity is still considered to lack specific memory, largely because there is no evidence of mechanisms that could provide such memory (such as acquired immunity).
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Helicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins
Frontiers in Immunology, 2023Silja Wessler +2 more
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Innate immune memory after brain injury drives inflammatory cardiac dysfunction
CellSebastian Clauss +2 more
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Fungal mediated innate immune memory, what have we learned?
Seminars in Cell and Developmental Biology, 2019Jessica Quintin
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