Distinct roles for innexin gap junctions and hemichannels in mechanosensation [PDF]
eLife, 2020 Mechanosensation is central to a wide range of functions, including tactile and pain perception, hearing, proprioception, and control of blood pressure, but identifying the molecules underlying mechanotransduction has proved challenging.
Denise S Walker, William R Schafer
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A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel [PDF]
Molecular Brain, 2011 Gap junctions mediate the electrical coupling and intercellular communication between neighboring cells. Some gap junction proteins, namely connexins and pannexins in vertebrates, and innexins in invertebrates, may also function as hemichannels.
Bouhours Magali +7 more
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Six innexins contribute to electrical coupling of C. elegans body-wall muscle. [PDF]
PLoS ONE, 2013 C. elegans body-wall muscle cells are electrically coupled through gap junctions. Previous studies suggest that UNC-9 is an important, but not the only, innexin mediating the electrical coupling.
Ping Liu +7 more
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Innexin 3, a new gene required for dorsal closure in Drosophila embryo. [PDF]
PLoS ONE, 2013 BACKGROUND:Dorsal closure is a morphogenetic event that occurs during mid-embryogenesis in many insects including Drosophila, during which the ectoderm migrates on the extraembryonic amnioserosa to seal the embryo dorsally.
Fabrizio Giuliani +3 more
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Dysregulation of Glial Gap Junction Protein Innexin2 Mediates Seizures and Disrupted Sleep in a Drosophila Model for North Sea Progressive Myoclonus Epilepsy. [PDF]
J Neurosci ResGlial Innexin2 expression plays a role in suppression of heat‐induced seizures and maintaining sleep architecture in Drosophila. A North Sea Progressive Myoclonus Epilepsy (NS‐PME) model shows a decreased level and altered expression pattern of glial Innexin2, along with heat‐induced seizures and disturbed sleep architecture.
Grzeschik NA +5 more
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Genetic engineering for SIT application: a fruit fly-focused review. [PDF]
Insect SciAbstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Davydova S, Yu D, Meccariello A.
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Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the
Neural Development, 2009 Background Approximately 10% of Caenorhabditis elegans nervous system synapses are electrical, that is, gap junctions composed of innexins. The locomotory nervous system consists of several pairs of interneurons and three major classes of motor neurons ...
Nicholson Bruce J +4 more
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ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response in C. elegans. [PDF]
PLoS GeneticsDisruption of endoplasmic reticulum (ER) homeostasis activates the unfolded protein response (UPR) to restore proteostasis. Although defects in the secretory machinery can induce ER stress, whether specific trafficking components actively couple cargo ...
Liying Guan +5 more
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Innexin DNA-binding domains regulate Microplitis bicoloratus bracoviral transcription in symbiotic wasps [PDF]
iScienceSummary: Bracoviruses have two hosts: symbiotic wasps and infected hosts. Although symbiotic wasps and infected Spodoptera litura larva host bracoviruses, mature virions form only in the wasps after the integrated Microplitis bicoloratus bracovirus (MbBV)
Hong-Mei Tang +18 more
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Gap junction-mediated signaling coordinates Rhodopsin coupling for Drosophila color vision [PDF]
Biology OpenXuanshuo Zhang +4 more
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