Connexins evolved after early chordates lost innexin diversity [PDF]
eLife, 2022 Gap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins.
Georg Welzel, Stefan Schuster
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Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans) [PDF]
Frontiers in Cell and Developmental Biology, 2022 How to make a neuron, a synapse, and a neural circuit? Is there only one ‘design’ for a neural architecture with a universally shared genomic blueprint across species?
Leonid L. Moroz +2 more
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Six Innexins Contribute to Electrical Coupling of C. elegans Body-Wall Muscle [PDF]
PLoS ONE, 2013 C. elegans body-wall muscle cells are electrically coupled through gap junctions. Previous studies suggest that UNC-9 is an important, but not the only, innexin mediating the electrical coupling.
David Hall, Bojun Chen, Alan Shan
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Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification [PDF]
Advanced ScienceThe host‐parasite arms race involves complex molecular crosstalk mediated by protein–protein interactions (PPIs). Bioinformatic analyses can be used to predict both host‐parasite PPIs and potential drug targets in parasite genomes, but high‐quality ...
Dong Zhang +17 more
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Molecular and morphological approach to study the innexin gap junctions in Rhynchosciara americana [PDF]
Open Biology, 2021 Gap junctions mediate communication between adjacent cells and are fundamental to the development and homeostasis in multicellular organisms. In invertebrates, gap junctions are formed by transmembrane proteins called innexins.
Jorge Henrique Neves +3 more
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Connexins, Innexins, and Pannexins: From Biology to Clinical Targets
Biomolecules, 2021 In 1964, Loewenstein and Kanno [...]
Trond Aasen
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Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system [PDF]
Biology Open, 2020 Gap junctions are evolutionarily conserved structures at close membrane contacts between two cells. In the nervous system, they mediate rapid, often bi-directional, transmission of signals through channels called innexins in invertebrates and connexins ...
Eugene Jennifer Jin +3 more
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Polydnavirus Innexins Disrupt Host Cellular Encapsulation and Larval Maturation
Viruses, 2021 Polydnaviruses are dsDNA viruses associated with endoparasitoid wasps. Delivery of the virus during parasitization of a caterpillar and subsequent virus gene expression is required for production of an amenable environment for parasitoid offspring ...
Matthew Turnbull
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Innexins: Expression, Regulation, and Functions
Frontiers in Physiology, 2018 The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
José Luis Vega +2 more
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Gap junctions mediate discrete regulatory steps during fly spermatogenesis. [PDF]
PLoS Genetics, 2022 Gametogenesis requires coordinated signaling between germ cells and somatic cells. We previously showed that Gap junction (GJ)-mediated soma-germline communication is essential for fly spermatogenesis.
Yanina-Yasmin Pesch +12 more
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