Results 31 to 40 of about 1,143 (172)
Biomolecules, 2020 In Caenorhabditis elegans, gap junctions couple cells of the somatic gonad with the germline to support germ cell proliferation and gametogenesis. A strong loss-of-function mutation (T239I) affects the second extracellular loop (EL2) of the somatic INX-8
Todd Starich, David Greenstein
doaj +1 more source
Innexin Function: Minding the Gap Junction [PDF]
Current Biology, 2007 Gap junctions mediate intercellular communication and are critical for development and nervous system function. Initially thought to function solely as stand-alone molecules, it has now been shown that a stomatin-like protein regulates a gap junction channel in Caenorhabditis elegans.
Norman, Kenneth R. +1 more
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +72 more
wiley +1 more source
Pharmacological and Genetic Evidence for Gap Junctions as Potential New Insecticide Targets in the Yellow Fever Mosquito, Aedes aegypti. [PDF]
PLoS ONE, 2015 The yellow fever mosquito Aedes aegypti is an important vector of viral diseases that impact global health. Insecticides are typically used to manage mosquito populations, but the evolution of insecticide resistance is limiting their effectiveness. Thus,
Travis L Calkins, Peter M Piermarini
doaj +1 more source
Biotechnology and Bioengineering, Volume 120, Issue 9, Page 2588-2600, September 2023., 2023 Single‐cell RNA sequencing was employed for the first time in Sf9 insect cell culture, to study the production of recombinant adeno‐associated virus (rAAV) using a dual baculovirus expression vector system (BEVS). The results highlight significant heterogeneity within the cell population during production.
Nikolaus Virgolini +7 more
wiley +1 more source
A role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis. [PDF]
PLoS ONE, 2013 Gap junctions formed by two hemichannels from two neighboring cells are cell-to-cell communication channels; hemichannels are communication channels between intracellular and extracellular environments.
Tian Liu +6 more
doaj +1 more source
iScience, 2021 Summary: A neuronal circuit of ∼150 neurons modulates rhythmic activity-rest behavior of Drosophila melanogaster. While it is known that coherent ∼24-hr rhythms in locomotion are brought about when 7 distinct neuronal clusters function as a network due ...
Aishwarya Ramakrishnan, Vasu Sheeba
doaj +1 more source
Connexin45 colocalization patterns in the plexiform layers of the developing mouse retina
Journal of Anatomy, Volume 243, Issue 2, Page 258-264, August 2023., 2023 Abstract Chemical and electrical synapses (gap junctions) are widely prevalent in the nervous system. Gap junctions emerge long before chemical synapses, allowing communication between developing cells, and are thought to be involved in establishing neural circuits.
Gerrit Hilgen
wiley +1 more source
Innexins: a family of invertebrate gap-junction proteins [PDF]
Trends in Genetics, 1998 In vertebrates, intercellular communication via gap junctions is mediated by the connexin family of molecules, which is made up of at least 13 members (reviewed in Ref. 1). These proteins, which have four transmembrane domains and intracellular C- and N-termini, oligomerize to form hemichannels.
P, Phelan +15 more
openaire +2 more sources
Frontiers in Physiology, 2014 As in other multicellular organisms, the nematode Caenorhabditis elegans uses gap junctions to provide direct cell-to-cell contact. The nematode gap junctions are formed by innexins (invertebrate analogs of the connexins); a family of proteins that ...
Karina eSimonsen +3 more
doaj +1 more source