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Metabolism and Function of myo-Inositol and Inositol Phospholipids
Annual Review of Nutrition, 1986Alterations in the level of dietary inositol can significantly influence the concentration of free inositol and inositol-containing phospholipid in the circulation and in selected mammalian tissues and cells. The 1-stearoyl 2-arachidonyl molecular species that commonly predominates in cellular phosphoinositides may be of considerable importance for the
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Antagonistic Effect of Inositol Pentakisphosphate on Inositol Triphosphate Receptors
Biochemical and Biophysical Research Communications, 1996We present evidence that inositol 1,3,4,5,6-pentakisphosphate acts as an antagonist of inositol triphosphate receptors in vitro by dampening the activity of Ca(2+)-mobilizing inositol phosphates. This antagonism bears physiological significance as cells maintain substantial quantities of this phosphoinositol in the cytosol, especially during cell ...
P J, Lu, W R, Shieh, C S, Chen
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The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate
Nature, 1994Activation of intracellular Ca2+ channels by inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) represents the initial Ca2+ mobilization step in response to many extracellular signals. Here we report that Ins(1,4,5)P3-induced channel activation in permeabilized hepatocytes is followed by a time-dependent inactivation, which is a direct consequence of ligand ...
G, Hajnóczky, A P, Thomas
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Multitarget Activities of Inositol and Inositol Hexakisphosphate
2020Multiple health beneficial effects have been shown for inositol hexakisphosphate (IP6) and its parent compound myo-inositol (Ins) in animal and human studies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades.
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The metabolism and functions of inositol pentakisphosphate and inositol hexakisphosphate
Biochemical Society Transactions, 1989D, Carpenter +5 more
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Molecular Cell, 2021Zhen Cai, Bo-Syong Pan, Haiwei Gu
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