Journal of Integrative Plant Biology, EarlyView.The Mediator subunit SlMED25 and the co‐repressor SlSPX2 competitively bind the N‐terminal domain of the phosphate starvation response transcription factor SlPHR3 in tomato to form a sensitive molecular switch, which dynamically modulates phosphate starvation responses and maintains phosphate homeostasis, offering valuable targets for breeding low ...
Mingtong Zhai +10 more
wiley +1 more source
Inositol supplementation efficacy in improving key cardiometabolic and anthropometric indices: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. [PDF]
Diabetol Metab SyndrDelavar MA +5 more
europepmc +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Serum LBP and zonulin levels with brain MRS findings and gastrointestinal symptoms in schizophrenia and health. [PDF]
Brain Behav Immun HealthTurek A +11 more
europepmc +1 more source
Dehydration‐driven organization of metabolites into NaDES‐like assemblies in orthodox seeds
New Phytologist, EarlyView.Summary Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold‐spray ionization mass spectrometry to ...
Youcef Haddad +11 more
wiley +1 more source
Cocrystal Formation of Quercetin and Nutraceutical Coformers via a Facile Technique with Improved Solubility and Biological Properties. [PDF]
ACS OmegaThavornnart P +6 more
europepmc +1 more source
New Phytologist, EarlyView.Summary Metabolic engineering of vegetative tissues for lipid production holds transformative potential for sustainable biofuels, yet achieving sufficient yields remains challenging. Here, we present a strategy to enhance fatty acid synthesis by redirecting cytosolic phosphoenolpyruvate (PEP) into plastids through overexpression of the plastidial ...
Jiang Wang +6 more
wiley +1 more source
Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration. [PDF]
Vet SciDondi M +9 more
europepmc +1 more source
Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance
New Phytologist, EarlyView.Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap +3 more
wiley +1 more source
Unveiling the Plasmodium inositol (pyro)phosphate pathway: Highlighting inositol polyphosphate multikinase as a novel therapeutic target for malaria. [PDF]
PLoS OneObuobi A +3 more
europepmc +1 more source