Results 61 to 70 of about 582,708 (219)
Calcium signalling in oomycetes: an evolutionary perspective
Frontiers in Physiology, 2016 Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being ...
John James Mackrill, Limian eZheng
doaj +1 more source
Bok: real killer or bystander with non-apoptotic roles?
Frontiers in Cell and Developmental Biology, 2023 Bcl-2-related ovarian killer, Bok, was first labeled “pro-apoptotic” due to its ability to cause cell death when over-expressed. However, it has become apparent that this is not a good name, since Bok is widely expressed in tissues other than ovaries ...
Caden G. Bonzerato +1 more
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Cell Reports, 2021 Summary: Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels that link extracellular stimuli to Ca2+ signals. Ca2+ release from intracellular stores is “quantal”: low IP3 concentrations rapidly release a fraction of the stores.
Ana M. Rossi +5 more
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iScience, 2023 Summary: The forebrain cholinergic system promotes higher brain function in part by signaling through the M1 muscarinic acetylcholine receptor (mAChR). Long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission in the
Tomonari Sumi, Kouji Harada
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Advanced Science, EarlyView.The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun +7 more
wiley +1 more source
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]
, 2012 Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J. +103 more
core +2 more sources
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]
, 2003 The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core
Cells, 2022 Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by activating the ionotropic GABAA receptors on cerebrovascular endothelial cells ...
Sharon Negri +8 more
doaj +1 more source
Taste‐Active Peptides: Sensation Mechanisms and Structure–Taste Relationships
Sensory Neuroscience, EarlyView.Overview of taste‐active peptides, including taste bud cellular organization, peptide–receptor interactions and signaling pathways, structure–taste relationships, and integrated computational and experimental strategies for peptide discovery, mechanism elucidation, and flavor modulation.
Dengyi Pei +4 more
wiley +1 more source