Results 51 to 60 of about 582,708 (219)

mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling. [PDF]

PLoS ONE, 2013
Autophagy is a lysosomal degradation pathway important for cellular homeostasis and survival. Inhibition of the mammalian target of rapamycin (mTOR) is the best known trigger for autophagy stimulation.
Jean-Paul Decuypere, Dimphny Kindt, Tomas Luyten, Kirsten Welkenhuyzen, Ludwig Missiaen, Humbert De Smedt, Geert Bultynck, Jan B Parys   +7 more
doaj   +1 more source

Selective determinants of inositol 1,4,5‐trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5‐trisphosphate receptors [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEAdenophostin A (AdA) is a potent agonist of inositol 1,4,5‐trisphosphate receptors (IP3R). AdA shares with IP3the essential features of all IP3R agonists, namely structures equivalent to the 4,5‐bisphosphate and 6‐hydroxyl of IP3, but the basis of its increased affinity is unclear.
Rossi, A, Sureshan, K, Riley, A, Potter, B, Taylor, C   +4 more
openaire   +3 more sources

Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion [PDF]

, 2003
Fertilization increases both cytosolic Ca(2+) concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure.
Smith, Peter J., Cibert, Christian, Porterfield, Marshall, Rouviere, Christian, Sardet, Christian, Hammar, Katherine, Porterfield, D. Marshall, Smith, Peter J. S., Dumollard, Remi, Hammar, Katherine M.   +9 more
core   +1 more source

The Clustering of Inositol 1,4,5-Trisphosphate (IP3) Receptors Is Triggered by IP3 Binding and Facilitated by Depletion of the Ca2+ Store

Journal of Pharmacological Sciences, 2008
The inositol 1,4,5-trisphosphate receptors (IP3Rs) form clusters following agonist stimulation, but its mechanism remains controversial. In this study, we visualized the clustering of green fluorescent protein (GFP)-tagged type 3 IP3R (GFP-IP3R3) in ...
Yosuke Tojyo, Takao Morita, Akihiro Nezu, Akihiko Tanimura   +3 more
doaj   +1 more source

Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. [PDF]

PLoS ONE, 2010
BACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate various vital processes. Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown
Keiko Uchida, Megumi Aramaki, Maki Nakazawa, Chihiro Yamagishi, Shinji Makino, Keiichi Fukuda, Takeshi Nakamura, Takao Takahashi, Katsuhiko Mikoshiba, Hiroyuki Yamagishi   +9 more
doaj   +1 more source

Structure and Function of Inositol 1,4,5-Trisphosphate Receptor

Japanese Journal of Pharmacology, 1997
Generation of intracellular Ca2+ signals in response to Ca(2+)-mobilizing stimuli is a critical event in the control of many cellular processes. Inositol 1,4,5-trisphosphate (IP3) represents a dominant second messenger subserving the release of Ca2+ from intracellular store sites.
Yoshida, Yutaka, Imai, Shoichi
openaire   +2 more sources

Role of Inositol-1,4,5-Trisphosphate Receptor in the Regulation of Calcium Transients in Neonatal Rat Ventricular Myocytes

Journal of Pharmacological Sciences, 2014
This study determined the regulatory effect of inositol 1,4,5-trisphosphate receptors (IP3Rs) on the basal Ca2+ transients in cardiomyocytes. In cultured neonatal rat ventricular myocytes (NRVMs) at different densities, we used confocal microscopy to ...
Zheng Zeng, Heping Zhang, Na Lin, Man Kang, Yuanyuan Zheng, Chen Li, Pingxiang Xu, Yongquan Wu, Dali Luo   +8 more
doaj   +1 more source

Are there subtypes of the inositol 1,4,5-trisphosphate receptor? [PDF]

Biochemical Journal, 1990
We have compared the properties of the [3H]Ins(1,4,5)P3-binding sites from a number of tissues in an attempt to determine if heterogeneity exists within the Ins(1,4,5)P3-receptor family. The binding of Ins(1,4,5)P3 was characterized in detail by using membranes prepared from human uterine smooth muscle and bovine adrenal cortex.
M A, Varney, J, Rivera, A, Lopez Bernal, S P, Watson   +3 more
openaire   +2 more sources

Inositol 1,4,5-Trisphosphate and Calcium Regulate the Calcium Channel Function of the Hepatic Inositol 1,4,5-Trisphosphate Receptor [PDF]

Journal of Biological Chemistry, 1997
The regulation of the inositol 1,4,5-trisphosphate (IP3) receptor in liver was analyzed using a novel superfusion method. Hepatic microsomes were loaded with 45Ca2+, and superfused at high flow rates to provide precise control over IP3 and Ca2+ concentrations ([Ca2+]) and to isolate 45Ca2+ release from reuptake.
J F, Dufour, I M, Arias, T J, Turner
openaire   +2 more sources

Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes

iScience, 2021
Summary: Extracellular agonists linked to inositol-1,4,5-trisphosphate (IP3) formation elicit cytosolic Ca2+ oscillations in many cell types, but despite a common signaling pathway, distinct agonist-specific Ca2+ spike patterns are observed.
Juliana C. Corrêa-Velloso, Paula J. Bartlett, Robert Brumer, Lawrence D. Gaspers, Henning Ulrich, Andrew P. Thomas   +5 more
doaj   +1 more source