Results 101 to 110 of about 6,478 (207)

The Selective Bromodomain and Extra‐Terminal Domain (BET) Inhibitor RVX‐208 Reduces Cocaine‐Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens

Addiction Biology, Volume 31, Issue 1, January 2026.
Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko, Afshin Seyednejad, Jesse Engelhardt, Gregory C. Sartor   +3 more
wiley   +1 more source

Thermodynamics of Inositol Hexakisphosphate Interaction with Human Oxyhemoglobin [PDF]

Journal of Biological Chemistry, 1998
The interaction of inositol hexakisphosphate (IHP) with oxygenated human adult hemoglobin (Hb) was investigated at 25 degreesC. The affinity of IHP for oxygenated Hb is strongly pH-dependent, and potentiometric measurements of proton uptake and release upon IHP addition have shown that over the range between pH 8.0 and pH 6.0 in oxygenated Hb there are
I. MESSANA, ANGELETTI, Mauro, M. CASTAGNOLA, DE SANCTIS, Giampiero, E. DI STASIO, B. GIARDINA, PUCCIARELLI, Stefania, COLETTA, Massimiliano   +7 more
openaire   +4 more sources

Using organic phosphorus to sustain pasture productivity: A perspective [PDF]

, 2013
Organic phosphorus (P) in grazed pastures/grasslands could sustain production systems that historically relied on inorganic P fertiliser. Interactions between inorganic P, plants and soils have been studied extensively.
Condron, Leo M., Haygarth, P. M., Heaven, M. W., McDowell, Richard, Nash, D. M., Richardson, A. E., Turner, B. L., Watkins, M.   +7 more
core   +1 more source

Safety evaluation of pectin‐rich extract derived from Coffea arabica as food additive

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety assessment of the proposed use of pectin rich extract derived from Coffea arabica L. as a food additive. The proposed food additive consists of 70%–85% dietary fibres (of which the major part is pectin), 4%–6.5% proteins and substances of ...
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, José Manuel Barat Baviera, Gisela Degen, David Gott, Jean‐Charles Leblanc, Peter Moldeus, Ine Waalkens‐Berendsen, Detlef Wölfle, Agnieszka Mech, Alexandra Tard, Panagiota Zakidou, Laura Ruggeri   +27 more
wiley   +1 more source

PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase

FEBS Letters, 1999
A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5‐trisphosphate 3‐kinase. However, the expressed PiUS protein showed no detectable activity against inositol 1,4,5‐trisphosphate, nor the 1,3,4,5‐ or 3,4,5,6‐isomers of inositol ...
Schell, M J, Letcher, A J, Brearley, C A, Biber, J, Murer, H, Irvine, R F   +5 more
openaire   +3 more sources

Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments [PDF]

, 2013
Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport,
Berkowitz, O., Fenske, R., Finnegan, P.M., Hardy, G.E.S.J., Jost, R., Kollehn, D.O., Lambers, H., O'Brien, P.A.   +7 more
core   +2 more sources

Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast

Biotechnology and Bioengineering, Volume 122, Issue 12, Page 3486-3495, December 2025.
Plouviez et al. give a perspective on the terminology used for describing the mechanisms of polyphosphate accumulation in microalgae and yeast. Their differentiation of mechanisms is based on environmental P availability, polyP chemistry, genetics, or cellular function as described in recent literature.
Maxence Plouviez, Philipp Demling, Alexander Deitert, Jana Fees, Makarius Baier, Tobias Karmainski, Lars M. Blank, Benoit Guieysse   +7 more
wiley   +1 more source

Siderophore activity of myo-inositol hexakisphosphate in Pseudomonas aeruginosa

Journal of Bacteriology, 1994
myo-Inositol hexakisphosphate (InsP6), which is found in soil and most, if not all, plant and animal cells, has been estimated to have an affinity for Fe3+ in the range of 10(25) to 10(30) M-1. In this report, we demonstrate that the Fe-InsP6 complex has siderophore activity and is able to reverse the iron-restricted growth inhibition of Pseudomonas ...
A W, Smith, D R, Poyner, H K, Hughes, P A, Lambert   +3 more
openaire   +3 more sources

An optimized high‐throughput colorimetric assay for phytic acid quantification

Crop Science, Volume 65, Issue 6, November/December 2025.
Abstract Phytic acid (PA) is the primary storage form of phosphorus in seeds and is considered an anti‐nutritional factor because of its ability to chelate essential minerals, thereby reducing their bioavailability. However, identifying low‐PA mutants in large populations requires a cost‐effective, accurate, and high‐throughput screening method.
Ahmed O. Warsame
wiley   +1 more source

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang, Yixuan Chen, Bowei Li, Shuang Wu, Hang Liang, Xingyue Yang, Xiaozhen Li, Ping Sun, Guangjin Guo, Ting Li, Yuying Jia, Haijiao Li, Mengqi Bai, Jie Xu, Zhijie Liu, Wei Liu, Xiangkang Jiang, Hong Cai   +17 more
wiley   +1 more source