Results 101 to 110 of about 761,638 (295)

Phosphorus in pig diets [PDF]

, 2006
Pig feed is mainly based on cereals where phosphorus (P) is mostly present in inositol hexaphosphate (IP6), which is not readily available to monogastric animals.
Lyberg, Karin
core  

Valproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase

Scientific Reports, 2023
Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in the treatment of bipolar disorder. It was previously reported that the mood stabilizer valproate (VPA) increased phosphorylation of myo-inositol-3-phosphate ...
Kendall C. Case, Rachel J. Beltman, Mary Kay H. Pflum, Miriam L. Greenberg   +3 more
doaj   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Phosphorylation Regulates myo-Inositol-3-phosphate Synthase

Journal of Biological Chemistry, 2013
Background: myo-Inositol-3-phosphate synthase (MIPS) catalyzes the first step in de novo biosynthesis of inositol in eukaryotes. Results: MIPS is a phosphoprotein. Phosphorylation regulates the activity of yeast and human MIPS.
Rania M. Deranieh, Quan He, J. Caruso, M. Greenberg   +3 more
semanticscholar   +1 more source

Nuclear inositides

European Journal of Histochemistry, 2009
DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
N Divecha, JH Clarke, JR Halstead, M Roefs, C D’Santos   +4 more
doaj   +3 more sources

Interactions of phytate and myo-inositol phosphate esters (IP1-5) including IP5 isomers with dietary protein and iron and inhibition of pepsin.

Journal of Animal Science, 2012
Phytic acid (IP(6)) and myo-inositol phosphate esters (IP(1-5)), including IP(5) isomers prepared chemically and enzymatically with bacterial and fungal phytases, were examined for their effects on protein aggregation of soy protein and β-casein ...
Shi Yu, Shi Yu, A. Cowieson, C. Gilbert, P. Plumstead, S. Dalsgaard   +5 more
semanticscholar   +1 more source

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias [PDF]

, 2017
Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates.
Aoki, Junken, Bolognini, Daniele, Hansen, Anders Højgaard, Hudson, Brian D., Inoue, Asuka, Kawakami, Kouki, Kishi, Takayuki, Milligan, Graeme, Sergeev, Eugenia, Ulven, Trond   +9 more
core   +3 more sources

Structural Studies and Protein Engineering of Inositol Phosphate Multikinase*

Journal of Biological Chemistry, 2012
Background: IPMK is a key enzyme in signaling required for cellular adaptation and organismal development. Results: We report the structure of IPMK, use structure-based enzyme design and perform complementation analysis in model systems.
S. Endo-Streeter, M. Tsui, A. Odom, J. Block, J. York   +4 more
semanticscholar   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

A truncated lipoglycan from mycobacteria with altered immunological properties [PDF]

, 2010
Maintenance of cell-wall integrity in Mycobacterium tuberculosis is essential and is the target of several antitubercular drugs. For example, ethambutol targets arabinogalactan and lipoarabinomannan (LAM) biosynthesis through the inhibition of several ...
Alderwick, Luke J., Appelmelk, B. J., Besra, Gurdyal S, Bhatt, Apoorva, Birch, Helen, Eggeling, Lothar, Geurtsen, J, Maaskant, J, Nigou, Jerome, Singh, Albel   +9 more
core   +2 more sources