Results 111 to 120 of about 494,776 (288)

Study of the regulation of Fab1p, a phosphatidylinositol 3-phosphate 5 kinase in Saccharomyces cerevisiae. [PDF]

, 2005
The Saccharomyces cerevisiae protein Fab1p is the archetypal type III phosphatidyl inositol phosphate kinase. This family of enzymes is universal to all eukaryotes and is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate from ...
Phelan, J.P., Phelan, John Paul
core  

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Plant responses to iron nutrition with emphasis on the underutilized crop tef (Eragrostis tef): A review

PLANTS, PEOPLE, PLANET, EarlyView.
Iron (Fe) deficiency limits the physical health, cognitive development, and economic output of billions of people globally, especially children and productive‐age women. Tef is an underutilized and stress‐resilient crop, which is becoming popular for its grains containing high bioavailable Fe and has the potential to mitigate Fe deficiency.
Muhammad Numan, David Remington, Ayalew Ligaba‐Osena   +2 more
wiley   +1 more source

Cadmium and arsenite rewire redox-linked phosphate metabolism in human iPSC-derived lung organoids

Redox Biochemistry and Chemistry
Environmental exposure to redox-active metal and metalloids such as cadmium (Cd) and arsenic (As) during early development poses significant risks to lung health, yet the underlying metabolic mechanisms remain poorly understood.
Dongxue Wang, ViLinh Tran, Anna G. Griggs, Adriana Harbuzariu, Dean P. Jones, Xin Hu   +5 more
doaj   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

The myo-inositol-1-phosphate synthase gene is essential in Tryponosoma brucei

, 2005
The de novo synthesis of myo-inositol occurs via a two-step process: first, glucose 6-phosphate is converted into inositol 1-phosphate by an IN01 (myo-inositol-1-phosphate synthase; EC 5.5.1.4); then, it is dephosphorylated by an inositol monophosphatase.
Smith, Terry K, Martin, K L
core   +2 more sources

A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery

SLAS Discovery
Inositol-tetrakisphosphate 1-kinase (ITPK1) is a pivotal enzyme in the inositol phosphate signaling pathway that functions to maintain the balance of inositol phosphate (IP) species.
Adam Yasgar, Sankalp Jain, Huanchen Wang, Chih-Shia Lee, Guangning Zong, Haibo Zhang, Eric Lindberg, Carolyn Woodroofe, Kelly Lane, Burchelle Blackman, Dan Crooks, Hsiuling Lin, Bolormaa Baljinnyam, Michael Ronzetti, Anton Simeonov, Sandeep Rana, Ganesha Rai, Stephen Shears, Robin E. Stanley, Alexey V. Zakharov, Ji Luo, Natalia J. Martinez   +21 more
doaj   +1 more source

myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei

, 2012
myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via ...
Gonzalez-Salgado, A., Bütikofer, P., Monika Rauch, Pascal Mäser, Rauch, Monika, Sigel, Erwin, Erwin Sigel, Greganova, Eva, Steinmann, M. E., Mäser, Pascal, Bütikofer, Peter, Rauch, M., Sigel, E., Michael E. Steinmann, Mäser, P., Amaia Gonzalez-Salgado, Gonzalez-Salgado, Amaia, Steinmann, Michael E, Eva Greganova, Peter Bütikofer, Greganova, E., Bütikofer P, Steinmann ME, Sigel E, Greganova E, Steinmann, Michael Eduard, Mäser P, Gonzalez-Salgado A, Rauch M   +28 more
core   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Stable Isotopomers of <i>myo-</i>Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network. [PDF]

ACS Cent Sci, 2022
Nguyen Trung M, Kieninger S, Fandi Z, Qiu D, Liu G, Mehendale NK, Saiardi A, Jessen H, Keller B, Fiedler D.   +9 more
europepmc   +1 more source