Results 131 to 140 of about 139,243 (282)

Structural basis of phosphate export by human XPR1

Nature Communications
Phosphorus in crucial for all living organisms. In vertebrate, cellular phosphate homeostasis is partly controlled by XPR1, a poorly characterized inositol pyrophosphate-dependent phosphate exporter.
Qixian He, Ran Zhang, Sandrine Tury, Valérie Courgnaud, Fenglian Liu, Jean-luc Battini, Baobin Li, Qingfeng Chen   +7 more
doaj   +1 more source

Adsorption of Inositol Phosphate on Hydroxyapatite Powder with High Specific Surface Area. [PDF]

Materials (Basel), 2022
Minamisawa H, Kojima Y, Aizawa M.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Effect of dietary calcium concentration and exogenous phytase on inositol phosphate degradation, mineral digestibility, and gut microbiota in growing pigs. [PDF]

J Anim Sci, 2023
Klein N, Sarpong N, Melzer T, Feuerstein D, Heyer CME, Camarinha-Silva A, Rodehutscord M.   +6 more
europepmc   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

The phytase RipBL1 enables the assignment of a specific inositol phosphate isomer as a structural component of human kidney stones. [PDF]

RSC Chem Biol, 2023
Liu G, Riemer E, Schneider R, Cabuzu D, Bonny O, Wagner CA, Qiu D, Saiardi A, Strauss A, Lahaye T, Schaaf G, Knoll T, Jessen JP, Jessen HJ.   +13 more
europepmc   +1 more source

Impacts of elevated atmospheric CO₂ on nutrient content of important food crops. [PDF]

, 2015
One of the many ways that climate change may affect human health is by altering the nutrient content of food crops. However, previous attempts to study the effects of increased atmospheric CO2 on crop nutrition have been limited by small sample sizes and/
Bloom, Arnold J, Carlisle, Eli, Dietterich, Lee H, Fernando, Nimesha, Fitzgerald, Glenn, Hasegawa, Toshihiro, Holbrook, N Michele, Huybers, Peter, Kloog, Itai, Leakey, Andrew DB, Myers, Samuel S, Nelson, Randall L, Norton, Robert, Ottman, Michael J, Raboy, Victor, Sakai, Hidemitsu, Sartor, Karla A, Schwartz, Joel, Seneweera, Saman, Usui, Yasuhiro, Yoshinaga, Satoshi, Zanobetti, Antonella   +21 more
core  

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. [PDF]

, 1992
We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that ...
Coughlin, SR, Hung, DT, Nelken, NA, Vu, TH   +3 more
core   +1 more source