Results 31 to 40 of about 1,340,779 (272)
Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice
Animal Cells and Systems, 2021 Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by widespread joint inflammation, which leads to joint damage, disability, and mortality.
Hyoungjoon Ahn +6 more
doaj +1 more source
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes [PDF]
Advances in Enzyme Regulation, 2010 Inositol phosphates and inositol pyrophosphates are small molecule metabolites that play important roles in nuclear processes such as transcription control, mRNA export and DNA repair. On this wonderful occasion of the fiftieth anniversary of the Advances in Enzyme Regulation conference, it is a privilege to participate through presenting recent ...
Marco M, Tsui, John D, York
openaire +2 more sources
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]
, 2008 Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen +15 more
core +1 more source
A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2017 Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient ...
Joonhyuk Choi +4 more
doaj +1 more source
mBio, 2023 Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez +4 more
doaj +1 more source
Intracellular signalling: Inositol phosphates – whither bound? [PDF]
Current Biology, 1996 AbstractMany proteins are being found to bind inositol phosphates with varying degrees of specificity; the variety of domains that can bind inositol phosphates suggests convergent evolution, but the functions of most of the binding sites are not yet clear.
Irvine, Robin, Cullen, Peter
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Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease
, 2021 Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes from yeasts to mammals, which are synthesized by a complex network of enzymes including inositol phosphate kinases.
Lee, Boah +4 more
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The inositol phosphate signalling network in physiology and disease [PDF]
Trends in Biochemical SciencesCombinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past
Seyun Kim +3 more
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The Inositol Phosphate System—A Coordinator of Metabolic Adaptability
, 2022 All cells rely on nutrients to supply energy and carbon building blocks to support cellular processes. Over time, eukaryotes have developed increasingly complex systems to integrate information about available nutrients with the internal state of energy ...
Tu-Sekine, Becky +3 more
core +1 more source
Characterization of the Inositol Monophosphatase Gene Family in Arabidopsis
Frontiers in Plant Science, 2015 Synthesis of myo-inositol is crucial in multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. The myo-inositol monophosphatase (IMP) enzyme is required for the synthesis of myo-inositol, breakdown of
Aida eNourbakhsh +2 more
doaj +1 more source