Inositol phosphate kinases in the eukaryote landscape
Advances in Biological Regulation, 2021 Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. To date, four distinct inositol kinases have been identified, namely, IPK, ITPK, IPPK (IP5-2K), and PPIP5K.
Debabrata Laha +3 more
openaire +4 more sources
Regulation of the Pho Regulon and Reconstruction of the Photosynthetic Apparatus under Phosphate Limitation in Synechocystis sp. PCC 6803 [PDF]
arXiv, 2021 For millennia, cyanobacteria have evolved strategies for acclimatization to dynamic environments- this requires a molecular response system. Phosphate is essential for cellular integrity and metabolism, yet inorganic phosphate is often the limiting nutrient for most aquatic environments.
arxiv
Change of Hydration Patterns upon RNA Melting Probed by Excitations of Phosphate Backbone Vibrations [PDF]
, 2020 The water hydration shell has decisive impact on the structural and functional properties of RNA. Changes of RNA structure upon melting and in biochemical processes are accompanied by a change of hydration patterns, a process which is barely characterized.
arxiv +1 more source
Transition behavior of the seizure dynamics modulated by the astrocyte inositol triphosphate noise [PDF]
, 2021 Epilepsy is a neurological disorder with recurrent seizures of complexity and randomness. Until now, the mechanism of epileptic randomness has not been fully elucidated. Inspired by the recent finding that astrocyte GTPase-activating protein (G-protein)-coupled receptors could be involved in stochastic epileptic seizures, we proposed a neuron-astrocyte
arxiv +1 more source
Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study [PDF]
, 2017 The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants. The physical and chemical properties of calcium phosphate coatings formed by RF-magnetron sputtering of calcium phosphate tribasic, hydroxyapatite, calcium phosphate monobasic, calcium phosphate ...
arxiv +1 more source
Nature Communications, 2020 Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation ...
Danye Qiu +14 more
doaj +1 more source
Elucidation of Inverse Agonist Activity of Bilastine
Pharmaceutics, 2020 H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity.
Hiroyuki Mizuguchi +9 more
doaj +1 more source
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
Ancient and recent collisions revealed by phosphate minerals in the Chelyabinsk meteorite [PDF]
arXiv, 2021 The collision history of asteroids is an important archive of inner Solar System evolution. Evidence for these collisions is brought to Earth by meteorites, which can preserve impact-reset radioisotope mineral ages. However, as meteorites often preserve numerous mineral ages, their interpretation is controversial. Here, we combine analysis of phosphate
arxiv
Contact Ion Pairs of Phosphate Groups in Water -- Two-Dimensional Infrared Spectroscopy of Dimethyl-Phosphate and Ab-Initio Simulations [PDF]
J. Phys. Chem. Lett. 2019, 10, 6281-6286, 2019 The interaction of phosphate groups with ions in an aqueous environment has a strong impact on the structure and folding processes of DNA and RNA. The dynamic variety of ionic arrangements, including both contact pairs and water separated ions, and the molecular coupling mechanisms are far from being understood.
arxiv +1 more source