Results 131 to 140 of about 98,783 (245)

Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT To investigate the potential bidirectional causal relationship between specific blood metabolites and chronic periodontitis using Mendelian randomisation (MR). A two‐sample bidirectional MR analysis was conducted. Data on 1400 blood metabolites were obtained from a genome‐wide association study involving 8299 participants.
Weilun Cai, Huaxuan Zhao, Panpan Wang, Xiao Chen, Yumeng Yang, Hongle Wu, Zehao Chen, Fuchun Fang, Wei Qiu   +8 more
wiley   +1 more source

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

Journal of Fungi, 2016
Opportunistic fungi are a major cause of morbidity and mortality world-wide, particularly in immunocompromised individuals. Developing new treatments to combat invasive fungal disease is challenging given that fungal and mammalian host cells are ...
Cecilia Li, Sophie Lev, Adolfo Saiardi, Desmarini Desmarini, Tania C. Sorrell, Julianne T. Djordjevic   +5 more
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Linxia Liu, Dongqin Ding, Huiying Wang, Xinyi Ren, Sang Yup Lee, Dawei Zhang   +5 more
wiley   +1 more source

Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. [PDF]

Chemistry, 2016
AbstractThe inositol pyrophosphate messengers (PP‐InsPs) are emerging as an important class of cellular regulators. These molecules have been linked to numerous biological processes, including insulin secretion and cancer cell migration, but how they trigger such a wide range of cellular responses has remained unanswered in many cases.
Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D.   +6 more
europepmc   +5 more sources

Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life

BioEssays, Volume 47, Issue 10, October 2025.
Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing recent research that highlights the critical role of Ap4A as a global regulator across all domains of life.
Gert Bange, Jennifer N. Andexer, Henning J. Jessen, Johannes Freitag, Sonja‐Verena Albers, Jan Pané‐Farré   +5 more
wiley   +1 more source

Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. [PDF]

, 2018
In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant ...
Debler, Erik W., Kafková, Lucie, Paul, Kimberly S., Pazzo, Kyle L., Qu, Jun, Read, Laurie K., Smith, Kyle P., Tu, Chengjian   +7 more
core   +2 more sources

UFMylation System: Biological Functions, Molecular Mechanisms, Diseases, and Drug Discovery

MedComm, Volume 6, Issue 10, October 2025.
UFMylation, a novel ubiquitin‐like modification, plays an essential role in various cellular processes, such as the immune response, DNA damage repair, unfolded protein response (UPR), autophagy, endoplasmic reticulum (ER)‐phagy, stem cell self‐renewal, apoptosis, and metastasis.
Huiyan Li, Fei Meng, Junjie Liang, Yijie Wang, Changliang Shan, Yan Chen   +5 more
wiley   +1 more source

Mast cell activation by pedicellarial toxin of sea urchin, Toxopneustes pileolus [PDF]

, 1927
Pedicellarial toxin, partially purified from the sea urchin Toxopneustes pileolus, dose-dependently and time-dependently caused histamine release from rat peritoneal mast cells.
Masao Takei, Hideyuki Nakagawa, Koichi Endo, Fugiwara, Okada, Endean, Alender, Mebs, Kimura, Kimura, Nakagawa, Takei, Ishizaka, Ishizaka, White, Beaven, Kimura, Saeki, Németh, Shore, Tsien, Mustelin, Bradford, Berridge, Grandt, Okajima, Schnefel, Sullivan, Metzer, Takei, Penner, Takei, Imboden, Lo   +33 more
core   +1 more source

A comparative study of the phosphorus characteristics of oil palm volcanic soils in Papua New Guinea and New Zealand volcanic soils : a thesis presented in partial fulfillment of the requirements for the Degree of Master of Applied Science in Soil Science at Massey University [PDF]

, 1998
Oil Palm (Elaeis guineensis Jacq.) grown on volcanic ash soils in Papua New Guinea (PNG) generally respond well to N fertilisers but shows a lack of consistent response to inorganic phosphorus (P) fertilisers.
Banabas, Murom
core