Results 141 to 150 of about 12,071 (167)

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

PLoS One, 2016
Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.   +8 more
europepmc   +1 more source

Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling with ¹⁸O-Water. [PDF]

J Am Chem Soc
Kim GD, Liu G, Qiu D, De Leo MG, Gopaldass N, Hermes J, Timmer J, Saiardi A, Mayer A, Jessen HJ.   +9 more
europepmc   +1 more source

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Phosphorylation of Proteins by Inositol Pyrophosphates

Science, 2004
The inositol pyrophosphates IP 7 and IP 8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified.
Solomon H. Snyder, Rashna Bhandari, Adam C. Resnick, Adele M. Snowman, Adolfo Saiardi   +4 more
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Inositol pyrophosphates: metabolism and signaling

Cellular and Molecular Life Sciences, 2006
Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. Since the discovery of inositol pyrophosphates in the early 1990s, enormous progress has been achieved in characterising this class of molecules, linking their biological presence to a wide range of cellular functions ...
M. Bennett, S. M. N. Onnebo, Adolfo Saiardi, Cristina Azevedo   +3 more
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Inositol pyrophosphates: between signalling and metabolism

Biochemical Journal, 2013
The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic ‘high energy’ pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be
Miranda S. C. Wilson, Adolfo Saiardi, Thomas M. Livermore   +2 more
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Inositol pyrophosphates: structure, enzymology and function

Cellular and Molecular Life Sciences, 2009
The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Gian Carlo Gaboardi, Christopher Illies, Christopher J. Barker, Per Olof Berggren   +3 more
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Photo-releasable derivatives of inositol pyrophosphates

2020
The specific non-invasive control of intracellular signaling events requires advanced tools that enter cells by diffusion and are controllable by light. Here, we detail the synthesis and application of membrane-permeant caged inositol pyrophosphates with respect to cell entry and cell distribution.
Hauke, Sebastian, Bittner, Tamara, Jessen, Henning, Schultz, Carsten   +3 more
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Understanding Inositol Pyrophosphates

Science's STKE, 2007
Inositol pyrophosphates are relatively poorly understood, highly phosphorylated members of the inositol polyphosphate family. Two studies describe related advances in signaling involving inositol pyrophosphates. Mulugu et al . purified an inositol pyrophosphate synthase from yeast, called Vip1. Lee et al
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Inositol Pyrophosphates in Metabolism Control

Science Signaling, 2011
Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
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A Discrete Signaling Function for an Inositol Pyrophosphate

Science's STKE, 2007
Inositol pyrophosphates were, until recently, without clearly defined functions. Two recent papers in Science have now clearly defined a function for an IP 7 pyrophosphate (inositol hexaphosphate with one pyrophosphate) that is the product of the enzyme encoded by the Vip1
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