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Cell Signalling by Inositol Pyrophosphates
2012Inositol serves as a module for the generation of a high level of molecular diversity through the combinatorial attachment and removal of phosphate groups. The array of potential inositol-containing molecules is further expanded by the generation of diphospho inositol polyphosphates, commonly referred as inositol pyrophosphates.
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Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
Science, 2011Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
Adolfo Saiardi +3 more
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Chemical tools for interrogating inositol pyrophosphate structure and function [PDF]
Chemical Society Reviews, 2016 New chemical and analytical tools have been developed to study the diverse functions of the inositol pyrophosphates, a unique group of densely phosphorylated intracellular metabolites found in a wide variety of eukaryotic organisms.
Nathaniel W. Brown +5 more
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Are inositol pyrophosphates signalling molecules?
Journal of Cellular Physiology, 2009AbstractThe inositol polyphosphate family of small, cytosolic molecules has a prominent place in the field of cell signalling, and inositol pyrophosphates are the most recent addition to this large family. First identified in 1993, they have since been found in all eukaryotic organisms studied.
Burton, Adam +2 more
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Biochemical Society Symposia, 2007
Among the many derivatives of the inositol-based signalling family are a subgroup that possess diphosphates. In this review, some recent research into the actions of these specialized polyphosphates is analysed, and key goals for future studies are identified, which, it is hoped, will result in the wider cell-signalling community giving considerably ...
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Among the many derivatives of the inositol-based signalling family are a subgroup that possess diphosphates. In this review, some recent research into the actions of these specialized polyphosphates is analysed, and key goals for future studies are identified, which, it is hoped, will result in the wider cell-signalling community giving considerably ...
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The Role of Inositol in Thyroid Physiology and in Subclinical Hypothyroidism Management
Frontiers in Endocrinology, 2021Salvatore Benvenga +2 more
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Understanding the Catabolism of Inositol Pyrophosphates in Plants
Inositol pyrophosphates (PP-InsPs) are vital nutrient messengers that finely regulate plant phosphate homeostasis, vital for growth and development. The enzyme VIP1, member of the PPIP5K kinase family, central to this network, generates the key signaling molecule 1,5-InsP8 and also participates in its breakdown. Alongside VIP1, Plant and Fungi Atypicalopenaire +2 more sources
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Molecular Cell, 2021Zhen Cai, Haiwei Gu, Chuan Xu
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