Results 151 to 160 of about 98,783 (245)

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks [PDF]

, 2018
Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases including cancer. Recent work has revealed that the poorly studied AGC kinase family member, SGK3 promotes resistance to cancer therapies that target the ...
Agoulnik, Alan R. Prescott, Alessi, Alessi, Amoasii, Annika Hornberger, Axe, Backer, Bago, Bago, Biondi, Bruhn, Brunet, Castel, Clark, Collins, Cross, Dario R. Alessi, Di Paolo, Downward, Ebner, Folkes, Fruman, Fulcher, Fulcher, Gan, García-Martínez, Gasser, Gillooly, Gonzalez-Sastre, Halland, Hannah Tovell, Hirai, Hirsch, Itakura, Kanai, Karen E. Anderson, Kim, Kimber, Kobayashi, Lemmon, Liu, Lodhi, Maffucci, Malek, Manning, Munson, Murray, Najafov, Nazma Malik, Nemazanyy, Ooms, Pearce, Pearce, Ran, Ronan, Sommer, Stokoe, Suwa, Tessier, Tessier, Thomas, Thomas Macartney, Virbasius, Yang   +64 more
core   +3 more sources

Reviewer #3 (Public Review): Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81

, 2023
Caroline Gutjahr, Kim Geun-Don, Qiu Danye, Liu Guizhen, Mayer Lydie Michaillat, Muhammed Jamsheer K., Jessen Henning Jacob, Mayer Andreas   +7 more
openalex   +1 more source

Unveiling the Plasmodium inositol (pyro)phosphate pathway: Highlighting inositol polyphosphate multikinase as a novel therapeutic target for malaria.

PLoS ONE
Plasmodium falciparum malaria is fatal if left untreated. Treatment is hampered by drug-resistant variants of the malaria parasite, highlighting the need to explore unique pathways for the development of new drugs with different mechanisms of action ...
Abigail Obuobi, Neils B Quashie, Nancy Odurowah Duah-Quashie, Jon R Sayers   +3 more
doaj   +1 more source

The plant Nudix hydrolase family. [PDF]

, 2008
Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core  

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]

, 2018
Jinsheng Zhu, Kelvin Lau, Robert K. Harmel, Robert Puschmann, Larissa Broger, Amit K. Dutta, Henning J. Jessen, Ludwig A. Hothorn, Dorothea Fiedler, Michael Hothorn   +9 more
openalex   +1 more source

Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

Nature Communications
Inorganic phosphate (Pi) has essential metabolic and structural roles in living organisms. The Pi exporter, XPR1/SLC53A1, is critical for cellular Pi homeostasis.
Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen, Melinda M. Diver   +4 more
doaj   +1 more source

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

Nature Communications
Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5K) generates the messenger 1,5-InsP8, the C-terminal phosphatase domain catalyzes PP-InsP breakdown ...
Pierre Raia, Kitaik Lee, Simon M. Bartsch, Felix Rico-Resendiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn   +8 more
doaj   +1 more source

Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis [PDF]

, 2019
Jinsong Dong, Guojie Ma, Liqian Sui, Mengwei Wei, Viswanathan Satheesh, Ruyue Zhang, Shenghong Ge, Jinkai Li, Tongen Zhang, Christopher Wittwer, Henning J. Jessen, Huiming Zhang, Guoyong An, Dai‐Yin Chao, Dong Liu, Mingguang Lei   +15 more
openalex   +1 more source

Correction for Rao et al., Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1 [PDF]

, 2020

openalex   +1 more source

Reviewer #1 (Public Review): Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

, 2023
C Valentin, Kim Geun-Don, Qiu Danye, Guizhen Liu, Mayer Lydie Michaillat, Muhammed Jamsheer K, Jessen Henning Jacob, Mayer Andreas   +7 more
openalex   +2 more sources