Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Cell Death and Disease, 2022 Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala +6 more
doaj +3 more sources
Insulin-like growth factor-1 and zinc
Turkish Journal of Hematology, 2008 Nejat Akar
doaj +2 more sources
Insulin-like Growth Factor 1 Signaling in Mammalian Hearing [PDF]
Genes, 2021 Insulin-like growth factor 1 (IGF-1) is a peptide hormone belonging to the insulin family of proteins. Almost all of the biological effects of IGF-1 are mediated through binding to its high-affinity tyrosine kinase receptor (IGF1R), a transmembrane receptor belonging to the insulin receptor family.
Ángela García-Mato +4 more
openaire +4 more sources
Heart Smart Insulin-Like Growth Factor 1 [PDF]
Hypertension, 2012 See related article, pp 680–693 The prevalence of obesity, metabolic syndrome, and type 2 diabetes mellitus, and the associated cardiac pathologies are rising to alarming levels. Conventional medical therapies for the prevention and treatment of cardiomyopathy are less effective in patients with these metabolic disorders, and this is attributed, at ...
Marsh, Susan A, Davidoff, Amy J
openaire +3 more sources
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]
, 2020 Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter +7 more
core +1 more source
Pasireotide for the Medical Management of Feline Hypersomatotropism [PDF]
, 2015 BACKGROUND: Feline hypersomatotropism (HST) is a cause of diabetes mellitus in cats. Pasireotide is a novel multireceptor ligand somatostatin analog that improves biochemical control of humans with HST.
Abraham +45 more
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Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]
, 2011 Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Börzsönyi, Balázs +7 more
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Microgravity, Bone Homeostasis, and Insulin-Like Growth Factor-1
Applied Sciences, 2020 Astronauts at are risk of losing 1.0–1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all designed to preserve ...
John Kelly Smith
doaj +1 more source
The signaling landscape of insulin-like growth factor 1. [PDF]
J Biol ChemThe sheer amplitude of biological actions of insulin-like growth factor I (IGF-1) affecting all types of cells in all tissues suggests a vast signaling landscape for this ubiquitous humoral signal. While the canonical signaling pathways primarily involve the Ras/MAPK and PI3K/AKT cascades, the evolutionary conservation of insulin-like peptides (ILPs ...
Khan MZ, Zugaza JL, Torres Aleman I.
europepmc +3 more sources
Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]
, 2017 Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F +6 more
core +1 more source