Results 51 to 60 of about 257,551 (158)

The Insulin/IGF system in colorectal cancer development and resistance to therapy

Frontiers in Oncology, 2015
The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri, Elena eTirrò, Maria Stella ePennisi, Michele eMassimino, Stefania eStella, Chiara eRomano, Livia eManzella   +6 more
doaj   +1 more source

Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro

Journal of Biological Chemistry, 1989
Insulin and Mn/MgATP treatment of immunoaffinity-purified alpha beta heterodimeric insulin receptors induced the formation of an alpha 2 beta 2 heterotetrameric insulin receptor complex. In contrast, insulin-like growth factor-1 (IGF-1) treatment was completely ineffective in inducing the association of alpha beta heterodimeric insulin receptors ...
J L, Treadway, B D, Morrison, I D, Goldfine, J E, Pessin   +3 more
openaire   +2 more sources

The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells

Medicina, 2019
Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells.
Seyed Ahmad Hosseini, Hamid Zand, Makan Cheraghpour   +2 more
doaj   +1 more source

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PLoS ONE, 2017
We have reported that integrins crosstalk with growth factors through direct binding to growth factors (e.g., fibroblast growth factor-1, insulin-like growth factor 1 (IGF1), neuregulin-1, fractalkine) and subsequent ternary complex formation with ...
Dora Maria Cedano Prieto, Yushen Cheng, Chih-Chieh Chang, Jessica Yu, Yoko K Takada, Yoshikazu Takada   +5 more
doaj   +1 more source

Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

Life Science Alliance, 2019
This study provides a novel function of the bacterial lectin LecB, which dampens cell proliferation and survival by targeting the insulin-like growth factor-1 for degradation, without receptor activation.
Alessia Landi, Muriel Mari, Svenja Kleiser, Tobias Wolf, Christine Gretzmeier, Isabel Wilhelm, Dimitra Kiritsi, Roland Thünauer, Roger Geiger, Alexander Nyström, Fulvio Reggiori, Julie Claudinon, Winfried Römer   +12 more
doaj   +1 more source

Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling

Journal of Neuroendocrinology, 2016
Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF1R) are highly conserved receptor tyrosine kinases that share signalling proteins and are ubiquitously expressed in the brain. Central application of insulin or IGF1 exerts several similar physiological outcomes, varying in strength, whereas disruption of the corresponding receptors in
openaire   +2 more sources

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

BMC Biology
Background Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease.
Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Andrew Ward   +3 more
doaj   +1 more source

Insulin-Like Growth Factor 1 Receptor [PDF]

, 2020
openaire   +1 more source

Effect of Electroacupuncture Intervention on Gastrointestinal Motility and Expression of Insulinlike Growth Factor 1 and Its Receptor Proteins in Gastric Antrum in Diabetic Gastroparesis Rats

针刺研究, 2017
Objective To observe the effect of electroacupuncture(EA)intervention of"Zusanli"(ST 36),etc.on gastrointestinal motility and levels of insulin-like growth factor 1(IGF-1)and IGF-1receptor(IGF-1R)proteins in the gastric antrum in diabetic gastroparesis ...
YANG Jian-wen, PENG Yan, CHEN Hai-jiao, ZHANG Cheng-cheng, LIU Wei-wei, LIU Li, LIU Mi, LIN Ya-ping   +7 more
doaj