Results 41 to 50 of about 257,551 (158)

Expression of insulin‐like growth factor‐1 receptor in keloid and hypertrophic scar

Clinical and Experimental Dermatology, 2014
Keloid and hypertrophic scar (HS) are two pathological forms of excessive dermal fibrosis, which are due to aberrant wound-healing responses. Accumulating evidence suggests that aberrant activity of growth factors and increased numbers of growth factor receptors play an important role in the formation of pathological scar.We examined the expression ...
Hu, Z-C, Tang, B, Guo, D, Zhang, J, Liang, Y-Y, Ma, D, Zhu, J-Y   +6 more
openaire   +2 more sources

The regulation of insulin receptor/insulin-like growth factor 1 receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1

Journal of Hematology & Oncology, 2022
Much higher risk of cancer has been found in diabetes patients. Insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) have been extensively studied in both breast cancer and diabetes therapies.
Thi Ngoc Quynh Nguyen, Samil Jung, Hai Anh Nguyen, BeomSuk Lee, Son Hai Vu, Davaajargal Myagmarjav, Hye Hyeon Eum, Hae-Ock Lee, Taeyeon Jo, Yeongseon Choi, Myeong-Sok Lee   +10 more
doaj   +1 more source

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

BMC Endocrine Disorders, 2018
Background Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP).
Hua-Pin Chang, Shun-Fa Yang, Shu-Li Wang, Pen-Hua Su   +3 more
doaj   +1 more source

Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor

Stem Cells International, 2019
As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat ...
Doaa Aboalola, Victor K. M. Han
doaj   +1 more source

Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives

Oncology Reviews, 2013
Based on over three decades of pre-clinical data, insulin-like growth factor-1 receptor (IGF-1R) signaling has gained recognition as a promoter of tumorogenesis, driving cell survival and proliferation in multiple human cancers.
Meizhong Jin, Elizabeth Buck, Mark J. Mulvihill   +2 more
doaj   +2 more sources

Differential Expression of Insulin-Like Growth Factor-I Receptor on Human Bone Marrow-Derived Mesenchymal Stem Cells Induced by Tumor Necrosis Factor-?

International Journal of Organ Transplantation Medicine, 2014
Background: Cell-based therapy has been implicated in the treatment of liver diseases. Mesenchymal stem cells from various sources such as bone marrow are available. These cells are one of the major candidates in cell therapy.
Z Sahraean, M Ayatollahi, R Yaghobi, M Shariati   +3 more
doaj  

Value of expression of insulin-like growth factor-1 receptor in gastric adenocarcinomas and normal gastric tissues

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Insulin-like growth factor-1 receptor (IGF-1R) plays critical roles in cell proliferation, differentiation, apoptosis, and transformation.
Ömer Topalak, Funda Uğur Kantar, Çağnur Ulukuş, Ali Küpelioğlu   +3 more
doaj   +1 more source

Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway

Frontiers in Cellular and Infection Microbiology, 2018
Antimicrobial peptides (AMPs) represent a promising area of research to help combat the ever-growing problem of antibiotic resistance. Protegrin-1 is an AMP from the cathelicidin family.
Jenna Penney, Jenna Penney, Julang Li, Julang Li   +3 more
doaj   +1 more source

Structural basis of the activation of type 1 insulin-like growth factor receptor

Nature Communications, 2019
The activation mechanism of type 1 insulin-like growth factor receptor (IGF1R) is not fully understood. Here, the authors determine the cryo-EM structure of full-length, IGF1-bound IGF1R in the active conformation, providing insights into how IGF1 ...
Jie Li, Eunhee Choi, Hongtao Yu, Xiao-chen Bai   +3 more
doaj   +1 more source

Decreased Expression of the Insulin-like Growth Factor 1 Receptor by Ribozyme Cleavage

Investigative Opthalmology & Visual Science, 2003
Insulin-like growth factor (IGF)-1 and its receptor (IGF-1R) are associated with abnormal retinal neovascularization. Ribozymes were designed that selectively decreased the expression of the IGF-1R and these ribozymes were tested in angiogenesis models in vitro and in vivo.Two hammerhead ribozymes were designed that cleave the human IGF-1R mRNA.
Lynn C, Shaw, Aqeela, Afzal, Alfred S, Lewin, Adrian M, Timmers, Polyxenie E, Spoerri, Maria B, Grant   +5 more
openaire   +2 more sources