Results 31 to 40 of about 113,429,372 (294)

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Frontiers in Endocrinology, 2018
Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Kiess, W., Kolb, H. J., Funk, B., Kessler, U., Hansmann, A.   +5 more
core   +1 more source

Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD.

PLoS ONE, 2018
Background and aimsNonalcoholic fatty liver disease is one of the major complications of obesity, occurring already in pediatric age. Insulin like growth factor-I has been proposed as a potential therapeutic agent for its beneficial effect in ...
Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati, Valerio Nobili, Stefano Cianfarani   +6 more
doaj   +1 more source

Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. [PDF]

PLoS ONE, 2012
BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R).
Ralph Epaud, Flore Aubey, Jie Xu, Zayna Chaker, Maud Clemessy, Alexandre Dautin, Karmène Ahamed, Monique Bonora, Nadia Hoyeau, Jean-François Fléjou, Arnaud Mailleux, Annick Clement, Alexandra Henrion-Caude, Martin Holzenberger   +13 more
doaj   +1 more source

Role of insulin-like growth factor 1 receptor signalling in cancer [PDF]

British Journal of Cancer, 2005
The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth.
Larsson, O, Girnita, A, Girnita, L
openaire   +3 more sources

MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer

Tumor Biology, 2017
MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer.
Hui Pang, Xiuying Yue
doaj   +1 more source

Insulin-Like Growth Factor-1 Receptor Expression in Thymic Malignancies [PDF]

Journal of Thoracic Oncology, 2010
Thymic epithelial tumors are rare mediastinal malignancies that can be invasive and difficult to treat. Insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor implicated in the regulation of cell metabolism, growth, and survival. As higher levels of IGF-1R protein expression may be associated with relative sensitivity to anti-IGF-1R
Girard, Nicolas, Teruya-Feldstein, Julie, Payabyab, Eden C., Riely, Gregory J., Rusch, Valerie W., Kris, Mark G., Zakowski, Maureen F.   +6 more
openaire   +2 more sources

Dual treatment of acromegaly and hormone-receptor-positive breast cancer with tamoxifen: a case report

Journal of Medical Case Reports, 2021
Background Adjuvant endocrine therapy is recommended for the treatment of hormone-receptor-positive breast cancer. Aromatase inhibitors are associated with significant musculoskeletal adverse effects, likely through growth hormone/insulin-like growth ...
Sasan Mirfakhraee, Alberto V. Cabo Chan, Niloofar Ganji, Jessica Abramowitz   +3 more
doaj   +1 more source

Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer

Frontiers in Endocrinology, 2017
The insulin-like growth factor-1 receptor (IGF1R) emerged in recent years as a promising therapeutic target in oncology. Identification of potential biomarkers capable of predicting response to IGF1R-targeted therapy is of cardinal importance.
Tali Cohen-Sinai, Tali Cohen-Sinai, Zoya Cohen, Haim Werner, Haim Werner, Raanan Berger   +5 more
doaj   +1 more source

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]

, 2005
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J, Whitelaw C. B. A., ACCORSI, PIER ATTILIO, Hurley, W, Boutinaud, M, Kolb A., Allan G. A., Tonner, E, Wilde, C J, Boutinaud M., Wilde C. J., Beattie J., Accorsi, P A, Flint, D J, Flint D. J., Tonner E., Whitelaw, C B A, Hurley W., Kolb, A F, Allan, G J   +19 more
core   +1 more source