Results 11 to 20 of about 257,551 (158)

Effect of IGF1Rβ Subunit Mutants on Proliferation, Migration and Apoptosis of Human Osteosarcoma Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the effect of IGF1R β subunit mutants sb-IGF1R and ma-IGF1R on the biological behavior of osteosarcoma 143B cells. Methods We designed and constructed sb-IGF1R and ma-IGF1R fragments.
WEN Zhongchi1, LIU Tuozhou1, HE Hongbo, ZHANG Can, LIU Yupeng, LIAO Zhan, ZENG Liyi   +6 more
doaj   +1 more source

Microgravity, Bone Homeostasis, and Insulin-Like Growth Factor-1

Applied Sciences, 2020
Astronauts at are risk of losing 1.0–1.5% of their bone mass for every month they spend in space despite their adherence to high impact exercise training programs and diets high in nutrients, potassium, calcium, and vitamin D, all designed to preserve ...
John Kelly Smith
doaj   +1 more source

Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. [PDF]

PLoS ONE, 2014
Pancreatic cancer is one of the most lethal cancers. Increasing incidence and mortality indicates that there is still much lacking in detection and management of the disease.
Ramadevi Subramani, Rebecca Lopez-Valdez, Arunkumar Arumugam, Sushmita Nandy, Thiyagarajan Boopalan, Rajkumar Lakshmanaswamy   +5 more
doaj   +1 more source

The contradictions of the insulin-like growth factor 1 receptor [PDF]

Oncogene, 2000
In recent years, the type 1 insulin-like growth factor receptor (IGF-IR) has emerged as a receptor that plays a very important role in the growth of cells, both in vivo and in vitro. The ability of the IGF-IR to induce mitogenesis and to promote survival of cells against a variety of apoptotic agents is well documented.
openaire   +2 more sources

Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer [PDF]

Cancer, 1989
In the current study the authors have investigated whether human primary breast cancer specimens contain insulin-like growth factor-1 (IGF-1) receptors (IGF-1-R) or IGF-1-like activities. Simultaneously, epidermal growth factor (EGF) receptors (EGF-R) and cytosolic estrogen receptor (ER), progesterone receptor (PR), and EGF-like activity were ...
J A, Foekens, H, Portengen, M, Janssen, J G, Klijn   +3 more
openaire   +2 more sources

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

Cloning and expression of full-length human insulin-like growth factor binding protein 3 (IGFBP3) in the Escherichia coli

Advanced Biomedical Research, 2015
Background: The effect of the growth hormone on target cells is mediated by the insulin-like growth factor 1 (IGF-1). IGF-1 binds to the insulin-like growth factor binding proteins (IGFBPs) in blood and biological fluids.
Emad Khodadadi, Mojtaba Panjepour, Mahdi Abbasian, Zahra Khalili Broujeni, Mohammad Reza Mofid   +4 more
doaj   +1 more source

Exosome-transported lncRNA H19 regulates insulin-like growth factor-1 via the H19/let-7a/insulin-like growth factor-1 receptor axis in ischemic stroke

Neural Regeneration Research, 2023
LncRNA (long non-coding RNA) H19 is a transcript of the H19 gene that is expressed during embryogenesis. We previously discovered a role for circular lncRNA H19 in the onset and prognosis of cerebral ischemic stroke.
Jue Wang, Bin Cao, Yan Gao, Yu-Hua Chen, Juan Feng   +4 more
doaj   +1 more source

Immunohistochemical evaluation of insulin-like growth factor receptor 1 in breast cancer [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2018
Introduction/Objective. Activation of insulin-like growth factor receptor (IGF-1R) results in cell transition from growth phase to synthesis phase of cell cycle.
Batinić-Škipina Danijela, Marić Radmil, Tadić-Latinović Ljiljana, Erić Dražan, Lalović Nenad   +4 more
doaj   +1 more source

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source