Results 21 to 30 of about 257,551 (158)
Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. [PDF]
PLoS ONE, 2014 The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases.
Zheng Liang +6 more
doaj +1 more source
Association of Insulin-like Growth Factor 1 Receptor with EHD1 and SNAP29 [PDF]
Journal of Biological Chemistry, 2001 Ligand-induced receptor-mediated endocytosis plays a central role in regulating signaling conveyed by tyrosine kinase receptors. This process depends on the recruitment of the adaptor protein 2 (AP-2) complex, clathrin, dynamin, and other accessory proteins to the ligand-bound receptor.
R, Rotem-Yehudar +2 more
openaire +2 more sources
IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
Frontiers in Endocrinology, 2018 Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj +1 more source
PLoS ONE, 2018 Background and aimsNonalcoholic fatty liver disease is one of the major complications of obesity, occurring already in pediatric age. Insulin like growth factor-I has been proposed as a potential therapeutic agent for its beneficial effect in ...
Anna Alisi +6 more
doaj +1 more source
Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R).
Ralph Epaud +13 more
doaj +1 more source
Role of insulin-like growth factor 1 receptor signalling in cancer [PDF]
British Journal of Cancer, 2005 The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor. IGF-1R is crucial for tumour transformation and survival of malignant cell, but is only partially involved in normal cell growth.
Larsson, O, Girnita, A, Girnita, L
openaire +3 more sources
Tumor Biology, 2017 MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer.
Hui Pang, Xiuying Yue
doaj +1 more source
Insulin-Like Growth Factor-1 Receptor Expression in Thymic Malignancies [PDF]
Journal of Thoracic Oncology, 2010 Thymic epithelial tumors are rare mediastinal malignancies that can be invasive and difficult to treat. Insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor implicated in the regulation of cell metabolism, growth, and survival. As higher levels of IGF-1R protein expression may be associated with relative sensitivity to anti-IGF-1R
Girard, Nicolas +6 more
openaire +2 more sources
Journal of Medical Case Reports, 2021 Background Adjuvant endocrine therapy is recommended for the treatment of hormone-receptor-positive breast cancer. Aromatase inhibitors are associated with significant musculoskeletal adverse effects, likely through growth hormone/insulin-like growth ...
Sasan Mirfakhraee +3 more
doaj +1 more source
Frontiers in Endocrinology, 2017 The insulin-like growth factor-1 receptor (IGF1R) emerged in recent years as a promising therapeutic target in oncology. Identification of potential biomarkers capable of predicting response to IGF1R-targeted therapy is of cardinal importance.
Tali Cohen-Sinai +5 more
doaj +1 more source