Results 251 to 260 of about 826,191 (386)

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

The Insulin-like Growth Factor Family as a Potential Peripheral Biomarker in Psychiatric Disorders: A Systematic Review. [PDF]

Int J Mol Sci
Fernández-Pereira C, Agís-Balboa RC.
europepmc   +1 more source

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Fluorescence-Based Multiplex Western Blot to Simultaneously Detect the Insulin-Like Growth Factor-1 (IGF-1) Isoforms. [PDF]

Electrophoresis
Bocconcelli M, Fanelli F, Saltarelli R, De Santi M, Barone R, Barbieri E, Annibalini G.   +6 more
europepmc   +1 more source

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.

, 1987
Tetsuro Izumi, Morris F. White, Takashi Kadowaki, Fumimaro Takaku, Y Akanuma, Masato Kasuga   +5 more
openalex   +1 more source

Regulation of insulin-like growth factor II receptors by growth hormone and insulin in rat adipocytes. [PDF]

, 1987
Peter Lönnroth, K Assmundsson, S Edén, Gösta Enberg, Ingrid Gause, K. Hall, Ulf Smith   +6 more
openalex   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Synergistic Effects of Insulin-like Growth Factor-1 and Platelet-Derived Growth Factor-BB in Tendon Healing. [PDF]

Int J Mol Sci
Rieber J, Wolint P, Meier-Bürgisser G, Ongini E, Giovanoli P, Calcagni M, Snedeker JG, Buschmann J.   +7 more
europepmc   +1 more source

Serum Form of the Rat Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor Is Truncated in the Carboxyl-terminal Domain

, 1989
Richard G. MacDonald, Mark A. Tepper, Kevin B. Clairmont, Susan B. Perregaux, M P Czech   +4 more
openalex   +1 more source

Insulin-Like Growth Factor-Binding Proteins in Hypophysectomized Rat Liver: Characterization and Subcellular Localization* [PDF]

, 1988
Bruno Barenton, B. Patel, Masood N. Khan, H. Guyda, Barry I. Posner   +4 more
openalex   +1 more source