Results 101 to 110 of about 635,173 (353)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Transparent Inorganic–Organic Bilayer Neural Electrode Array and Integration to Miniscope System for In Vivo Calcium Imaging and Electrophysiology

Advanced Functional Materials, EarlyView.
This study presents the BioCLEAR system, a highly transparent and conductive neural electrode array composed of silver nanowires (AgNWs) and doped PEDOT:PSS, enabling neural recordings with minimal optical artifacts. When integrated with a GRIN lens, this cost‐effective neural implant allows simultaneous electrophysiological recording and GCaMP6‐based ...
Dongjun Han, Kevin Cheng, Swathy Sampath Kumar, Anil Bollimunta, Elizabeth E. Torr, Juhwan Kim, Kyoungmin Kim, Hyungjun Choi, Seongkwon Hwang, Sarah Brodnick, David Cheng, Lindsay Gray, Yei Hwan Jung, William L. Murphy, Aaron J. Suminski, Jonathan J. Nassi, Justin C. Williams, Dong‐Wook Park   +17 more
wiley   +1 more source

Effect of Six Months of Aerobic Exercise on Serum Levels of Insulin, Growth Hormone and Insulin-Like Growth Hormone 1 in Sedentary Obese Women

Medical Laboratory Journal, 2018
Background and Objectives: Inactivity, obesity and hormone disorders can lead to various diseases in obese and non-athletic individuals. The objective of this study was to investigate effects of six months of aerobic exercise on serum levels of insulin ...
Mahtab Moazami, Babisan Askari
doaj  

Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula [PDF]

, 1991
Completely diverting portacaval shunt (Eck's fistula) in dogs causes hepatocyte atrophy, disruption of hepatocyte organelles, fatty infiltration and lowgrade hyperplasia. The effect of hepatic growth regulatory substances on these changes was assessed by
Azzarone, A, Barone, M, Carrieri, G, Foglieni, CS, Francavilla, A, Michalopoulos, GK, Porter, K, Starzl, TE, Trejo, J, Zeng, QH   +9 more
core   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

The impact of exercise on growth factors in postmenopausal women: a systematic review and meta-analysis

BMC Women's Health
Background Aging results in many changes in health status, body composition, muscle strength, and, ultimately, functional capacity. These changes coincide with significant alterations in the endocrine system, such as insulin-like growth factor-1 (IGF-1 ...
Yasaman Nasir, Mohammad Reza Hoseinipouya, Hesam Eshaghi, Mohammad Hossein Rahimi   +3 more
doaj   +1 more source

Expression of recombinant human insulin-like growth factor type 1 (rhiGF-1) in Escherichia Coli [PDF]

, 2015
Background: Human insulin-like growth factor type 1 (hIGF-1) is a protein consisting of 70 amino acids (MW=7.6 kDa) and mainly synthesized by liver.
Gharanjik, V., Iranpoor, H., Omidinia, E., Shahbazi, M., Vatankhah, V.   +4 more
core  

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study

Frontiers in Endocrinology
ObjectiveInsulin-like growth factor (IGF) is closely associated with sarcopenia, yet the causal relationship of this association remains unclear.
Jili Liu, Meng Chen, Xin Xia, Zhaolin Wang, Yanqin Wang, Ling Xi   +5 more
doaj   +1 more source

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Frontiers in Cellular Neuroscience, 2019
BackgroundExogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents.
Wei Chen, Bin He, Wusong Tong, Jinsong Zeng, Ping Zheng   +4 more
doaj   +1 more source