Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]
, 2014 Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M. +5 more
core +1 more source
Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La enfermedad trofoblástica gestacional comprende un conjunto de patologías caracterizadas por crecimiento e invasión anómalos del trofoblasto.
Yinth Andrea Bernal +6 more
doaj +1 more source
Relationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth
Acta Clinica Croatica, 2020 Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses.
Lidija Banjac +5 more
doaj +1 more source
Effect of Iron Deficiency Anemia on IGF-1 Level Among Sample of Children
Advanced Medical Journal, 2023 Background and objectives:Iron-deficiency anemia is a worldwide nutritional problem and an important public health problem especially in developing countries.
Kani Rast Noori +1 more
doaj +1 more source
Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]
, 2019 IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R +9 more
core +1 more source
Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling [PDF]
, 2014 The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium.
Brinchmann, Jan E. +4 more
core +7 more sources
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells [PDF]
, 2014 Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related ...
Oliveira, Ana M. +4 more
core +1 more source
The contradictions of the insulin-like growth factor 1 receptor [PDF]
Oncogene, 2000 In recent years, the type 1 insulin-like growth factor receptor (IGF-IR) has emerged as a receptor that plays a very important role in the growth of cells, both in vivo and in vitro. The ability of the IGF-IR to induce mitogenesis and to promote survival of cells against a variety of apoptotic agents is well documented.
openaire +3 more sources
Insulin-Like Growth Factor-1 in Acute Ischemic Stroke
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018 Background Cerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability.
Hala Shaheen +4 more
doaj +1 more source
Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development
Acta paediatrica, 2016 Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are ...
A. Hellström +11 more
semanticscholar +1 more source