Results 81 to 90 of about 635,173 (353)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Role of Insulin-like Growth Factor Binding Protein 3 as a Diagnostic Marker of Growth Hormone in Patients with Acromegaly

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
The paper studied the levels IGFBP-3 in patients with acromegaly, received different therapies. The findings showed that patients with acromegaly after surgical removal of a pituitary tumor, as well as after radiation therapy, the most sensitive ...
A.O. Kholikova
doaj   +1 more source

Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]

, 2015
Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P., Hammers, David W., Hsieh, Pei-Ling, Merscham-Banda, Melissa, Pham, Chantal B., Rybalko, Viktoriya Y., Suggs, Laura J.   +6 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Short hairpin RNA targeting insulin-like growth factor binding protein-3 restores the bioavailability of insulin-like growth factor-1 in diabetic rats

International Brazilian Journal of Urology, 2016
Purpose To investigate whether intracavernosal injection of short hairpin RNA for IGFBP-3 could improve erectile function in streptozotocin-induced diabetic rats.
Zhang-Yan Zhou, Guang-Jun Zhong, Shao-Ping Cheng, Hui Huang, Jing Wang, Hui Pan, Chang-Mao Liu, Cheng Xing, Ya-Ling Sun, Rong-Hua Liu, Fei-Li   +10 more
doaj   +1 more source

Insulin-like growth factor-1 levels in children with Beta-thalassemia minor [PDF]

, 2008
Objective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and ...
Hamdollah Karamifar, Mehran Karimi, Nargrs Sobhani   +2 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report

Journal of Medical Case Reports, 2010
Introduction Adult Growth hormone Deficiency is a well known phenomenon effecting both males and females. Adult Growth Hormone Deficiency is marked by a number of neuropsychiatric, cognitive performance, cardiac, metabolic, muscular, and bone symptoms ...
Madigan Margaret, Chen Thomas JH, Yeldandi Swetha, Damle Uma J, Bowirrat Abdalla, Braverman Eric R, Kerner Mallory, Huang Stanley X, Savarimuthu Stella, Blum Kenneth   +9 more
doaj   +1 more source

Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats. [PDF]

, 2006
Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth ...
Abe, Nobuhiro, Doi, Hideyuki, Kitamura, Ai, Komiyama, Takamitsu, Miyazawa, Shinichi, Nasu, Yoshihisa, Nishida, Keiichiro, Ozaki, Toshifumi, Yorimitsu, Masanori, Yoshida, Aki   +9 more
core   +1 more source