Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Human Keratinocyte Cell Line HaCaT [PDF]
, 1995 The human keratinocyte cell line HaCaT has a basal phenotype and secretes an insulin-like growth factor (IGF) binding protein, IGFBP-3, which modulates its IGF-I response.
Werther, George A. +1 more
core +1 more source
Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain [PDF]
, 2016 Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Collinsová, Michaela +13 more
core +1 more source
Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La enfermedad trofoblástica gestacional comprende un conjunto de patologías caracterizadas por crecimiento e invasión anómalos del trofoblasto.
Yinth Andrea Bernal +6 more
doaj +1 more source
Normal growth and development in the absence of hepatic insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America, 1999 The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I) was a hepatically derived circulating mediator of growth hormone and is a crucial factor for postnatal growth and development. To reassess this hypothesis, we have used the Cre/
S. Yakar +6 more
semanticscholar +1 more source
Obesity and breast cancer in premenopausal women: Current evidence and future perspectives [PDF]
, 2018 There is raising evidence reporting an increased incidence of breast cancer over the past decades. Every year approximately 1.4 million new cases of breast cancer are diagnosed worldwide, with a mortality rate of approximately 450,000/year.
Barrea, Luigi +4 more
core +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2006 Introducción. La citología cervico-uterina como prueba de tamizaje del cáncer cervical tiene limitaciones. Un marcador que permita identificar mujeres en riesgo de desarrollar este cáncer sería de utilidad para prevenir el desarrollo de esta enfermedad ...
Martha Lucía Serrano +4 more
doaj +1 more source
Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis [PDF]
, 2004 The Type I insulin-like growth factor receptor is a physiological receptor for insulin-like growth factor II (IGF-II). To characterize the molecular basis of the receptor's ligand binding properties, we have examined the effects of alanine mutations of ...
Baker +17 more
core +1 more source
Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. [PDF]
, 1996 We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity.
C J Auernhammer +4 more
core +1 more source
Human conditions of insulin-like growth factor-I (IGF-I) deficiency
Journal of Translational Medicine, 2012 Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
Puche Juan E, Castilla-Cortázar Inma
doaj +1 more source
Insulin-like growth factor I in essential hypertension
Kidney International, 1999 mmol/liter; serum cholesterol, 5.95 mmol/liter; serum triglycerides, 1.40 mmol/liter; serum potassium, 4 mmol/liter; serum creatinine, 95 mmol/liter (1.1 mg/dl); creatinine clearance, 112 ml/min/1.73 m body surface; and 24-hour urine albumin excretion, 245 mg. Urinalysis revealed no other abnormalities.
Principal discussant, , Díez, Javier
openaire +3 more sources