Results 21 to 30 of about 356,438 (307)

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

Journal of Translational Medicine, 2012
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
Puche Juan E, Castilla-Cortázar Inma
doaj   +1 more source

Growth Hormone Receptor Gene Expression Increase Reflects Nutritional Status Improvement in Patients Affected by Crohn's Disease

Frontiers in Pediatrics, 2018
Background: We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD).Methods: We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-
Sara Pagani, Elena Bozzola, Caterina Strisciuglio, Cristina Meazza, Erasmo Miele, M. Malamisura, Paola De Angelis, Mauro Bozzola   +7 more
doaj   +1 more source

Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2009
Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model of IGF-IR overexpression in the lung has not been created.
Nicolle M. Linnerth, Megan D. Siwicky, Craig I. Campbell, Katrina L.M. Watson, James J. Petrik, Jeffrey A. Whitsett, Roger A. Moorehead   +6 more
doaj   +1 more source

Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies

Neurobiology of Disease, 2001
The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes.
J.Robinson Singleton, Eva L. Feldman
doaj   +1 more source

Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

Hormone Research in Paediatrics, 2016
Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on the use of growth hormone (GH).
A. Grimberg, S. DiVall, C. Polychronakos, D. Allen, L. Cohen, J. B. Quintos, W. Rossi, C. Feudtner, M. Murad   +8 more
semanticscholar   +1 more source

Characteristics and treatment outcomes of micromegaly – acromegaly with apparently normal basal GH: A retrospective study and literature review

Endocrine Regulations, 2022
Objective. Micromegaly describes a subgroup of patients with clinically evident acromegaly and elevated insulin-like growth factor I (IGF-I) with apparently normal basal growth hormone (bGH) and often a glucose-suppressed growth hormone (GH) of
Inacio Isabel, Fonseca Liliana, Amado Ana, Benido Vania, Ribeiro Isabel, Dores Jorge, Amaral Claudia, Cardoso Maria Helena   +7 more
doaj   +1 more source

The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells

Medicina, 2019
Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells.
Seyed Ahmad Hosseini, Hamid Zand, Makan Cheraghpour   +2 more
doaj   +1 more source

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

Frontiers in Endocrinology, 2023
IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation.
Stefania Stella, Stefania Stella, Michele Massimino, Michele Massimino, Livia Manzella, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Silvia Rita Vitale, Federica Martorana, Federica Martorana, Paolo Vigneri, Paolo Vigneri, Paolo Vigneri   +13 more
doaj   +1 more source

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Journal of Neuroscience, 2000
Physical exercise increases brain activity through mechanisms not yet known. We now report that in rats, running induces uptake of blood insulin-like growth factor I (IGF-I) by specific groups of neurons throughout the brain.
E. Carro, Á. Núñez, S. Busiguina, I. Torres-Alemán   +3 more
semanticscholar   +1 more source

The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)

Animals, 2020
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan, Chaobin Qin, Guokun Yang, Dapeng Deng, Liping Yang, Junchang Feng, Jiali Mi, Guoxing Nie   +7 more
doaj   +1 more source