Endocrine Connections, 2018 The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the ...
Werner F Blum +6 more
doaj +1 more source
Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight. [PDF]
, 2013 BACKGROUND: In low-birth-weight girls, obesity increases the risk of premature adrenarche and metabolic complications. However, the consistency of this association in normal-birth-weight children and its potential mediators remain unknown.
Baquedano +45 more
core +1 more source
International Journal of Endocrinology, 2021 Insulin is important in glucose metabolism. However, insulin-like growth factor binding protein (IGFBP) also plays an important role in glucose homeostasis, although the IGF-independent role of IGFBP-3 in the glucose intolerance state is poorly ...
Sun-Young Kim +3 more
doaj +1 more source
Pregnancy rates and metabolic profiles in cattle treated with propylene glycol prior to embryo transfer [PDF]
, 2011 The objective of this study was to determine the effect of a sustained propylene glycol administration to recipients of frozen/thawed in vivo derived bovine embryos.
Duque, Paloma +8 more
core
Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome [PDF]
, 1999 Polycystic ovary syndrome (PCOS) is the most common cause of anovulation in women. Previous studies suggest that the pathogenesis of PCOS may involve interrelated abnormalities of the insulin-like growth factor (IGF) and ...
Faessen, G. +4 more
core +2 more sources
Multiple Myeloma in a Patient with Acromegaly [PDF]
Endocrinology and Metabolism, 2015 Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1
Yu Mi Kang +8 more
doaj +1 more source
Age-related loss of skeletal muscle function; impairment of gene expression. [PDF]
, 2004 Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation.
Goldspink, G
core
Bioactive Insulin-Like Growth Factor-I in Obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2009 In obesity, total IGF-I is not reduced to the degree predicted by low GH levels, and free IGF-I levels are normal to high. Total and free IGF-I may not reflect IGF-I biological activity because immunoassays cannot account for the modifying effects of IGF binding proteins on interactions between IGF-I and its receptor.The aim of the study was to ...
J. Frystyk +4 more
openaire +3 more sources
Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation [PDF]
Endocrinology and Metabolism, 2015 The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction.
Hyae Min Lee +8 more
doaj +1 more source
Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice [PDF]
, 2000 Genes influencing body weight and composition and serum concentrations of leptin, insulin, and insulin-like growth factor I (IGF-I) in nonfasting animals were mapped in an intercross of the extreme high-growth mouse line DU6i and the inbred line DBA/2 ...
Brockmann, G A +5 more
core +2 more sources