Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons [PDF]
Antioxidants, 2021 Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis.
Silvia Claros +9 more
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Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. [PDF]
Genes & Development, 1992 We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages.
Daniel A. Rappolee +5 more
semanticscholar +3 more sources
Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? [PDF]
Journal of Clinical Investigation, 1992 The pathogenesis of extrapancreatic tumor hypoglycemia has been related to the secretion of big insulin-like growth factor (IGF) II by the tumor.
J. Zapf, E. Futo, M Peter, E. R. Froesch
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Relationship between Metal Pollution and Gene Expression of Insulin-like Growth Factor II [PDF]
Journal of Health and Pollution, 2018 Background. Metals pollution plays an important role in the regulation of gene expression through interference with signal transduction pathways which are important for cell bioactivity. Objectives.
Aziza A. Saad +4 more
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Insulin-Like Growth Factor-II: Possible Local Growth Factor in Pheochromocytoma* [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1990 Pheochromocytomas, neural crest tumors, express an abundance of insulin-like growth factor-II (IGF-II). To assess further the potential for IGF-II to play an autocrine role for these tumors, we measured 1) IGF-II content by RRA in 7 pheochromocytomas and peripheral blood in these patients, 2) IGF-II receptors by Western analysis, and 3) characterized ...
Marie C. Gelato, Joseph A. Vassalotti
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Temporal expression pattern of the insulin-like growth factor II and fibroblast growth factor transcripts in avian embryogenesis [PDF]
Brazilian Archives of Biology and Technology, 2008 In this study, the abundance of IGF-II and bFGF transcripts was estimated in the chicken embryos using the competitive RT-PCR analysis. Significant enhancements in the abundance of IGF-II mRNA were observed at stages HH1 and 5, and a new accumulation in ...
Jane Eyre Gabriel +2 more
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine [PDF]
Stem Cell Reports, 2019 Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches.
Amber N. Ziegler +12 more
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New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations [PDF]
Cells, 2020 Insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II) play a crucial factor in the growth, differentiation and survival of cells in health and disease.
Joseph A.M.J.L. Janssen
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Endonucleolysis in the turnover of insulin-like growth factor II mRNA.
Journal of Biological Chemistry, 1992 The overlapping transcription units constituting the rat insulin-like growth factor II (IGF-II) locus generate multiple mRNAs by using different promoters. Three promoters have been identified, giving rise to 4.6-, 3.8-, and 3.6-kilobase mRNAs. The latter, originating from promoter P3, is the most abundant IGF-II mRNA in the rat liver cell-line BRL-3A.
Finn Cilius Nielsen, Jan Christiansen
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Endocrinology, 1998 Islet cell ontogeny will define adult beta-cell mass and will consist of a balance of islet cell birth and death. We have investigated the ontogeny of factors that may be related to developmental apoptosis in the islets, insulin-like growth factor II ...
Jim Petrik +3 more
semanticscholar +3 more sources