Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. [PDF]
Genes & Development, 1992 We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages.
Daniel A. Rappolee +5 more
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Temporal expression pattern of the insulin-like growth factor II and fibroblast growth factor transcripts in avian embryogenesis [PDF]
Brazilian Archives of Biology and Technology, 2008 In this study, the abundance of IGF-II and bFGF transcripts was estimated in the chicken embryos using the competitive RT-PCR analysis. Significant enhancements in the abundance of IGF-II mRNA were observed at stages HH1 and 5, and a new accumulation in ...
Jane Eyre Gabriel +2 more
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine [PDF]
Stem Cell Reports, 2019 Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches.
Amber N. Ziegler +12 more
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Insulin-Like Growth Factor-II: Possible Local Growth Factor in Pheochromocytoma*
The Journal of Clinical Endocrinology & Metabolism, 1990 Pheochromocytomas, neural crest tumors, express an abundance of insulin-like growth factor-II (IGF-II). To assess further the potential for IGF-II to play an autocrine role for these tumors, we measured 1) IGF-II content by RRA in 7 pheochromocytomas and peripheral blood in these patients, 2) IGF-II receptors by Western analysis, and 3) characterized ...
Marie C. Gelato, Joseph A. Vassalotti
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Endonucleolysis in the turnover of insulin-like growth factor II mRNA.
Journal of Biological Chemistry, 1992 The overlapping transcription units constituting the rat insulin-like growth factor II (IGF-II) locus generate multiple mRNAs by using different promoters. Three promoters have been identified, giving rise to 4.6-, 3.8-, and 3.6-kilobase mRNAs. The latter, originating from promoter P3, is the most abundant IGF-II mRNA in the rat liver cell-line BRL-3A.
Finn Cilius Nielsen, Jan Christiansen
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New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations [PDF]
Cells, 2020 Insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II) play a crucial factor in the growth, differentiation and survival of cells in health and disease.
Joseph A.M.J.L. Janssen
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Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1988 Fotini Stylianopoulou +3 more
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Primary structure of human insulin‐like growth factor II [PDF]
FEBS Letters, 1978 E. Rinderknecht, R. Humbel
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An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. [PDF]
PLoS GeneticsInsulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. Multiple mechanisms are proposed for how this altered signaling slows aging.
Marc Tatar +7 more
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Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? [PDF]
Journal of Clinical Investigation, 1992 J. Zapf, E. Futo, M Peter, E. R. Froesch
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