Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. [PDF]
J Biol Chem, 2016 Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Hexnerová R +13 more
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Definitions, 2020 Insulin-like growth factor II (180 aa, ~20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and mitogenesis.
semanticscholar +1 more source
Clinical Case Reports, 2021 Nonislet tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome characterized by refractory hypoglycemia, which often requires multifaceted therapy.
Mariko Ono +6 more
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Malignant fibroma presenting as a hypoglycemia and coma in a 45‐year‐old male patient: A case report
Clinical Case Reports, 2022 Solitary fibrous tumors (SFTs) are a rare group of spindle cell neoplasm of submesothelial origin with malignant potential and can present as hypoglycemia secondary to excess secretion of insulin‐like growth factor II (IGF‐II) from the tumor.
Muhammad Hanif +5 more
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Associations Between IGF-II Gene Polymorphism and Milk Yield Characteristics In Brown Swiss Cattle
Turkish Journal of Agriculture: Food Science and Technology, 2023 This study was carried out on 114 Brown Swiss cattle reared in intensive conditions at Ataturk University Food and Livestock Application and Research Center and at the private cattle farm found in Erzurum province.
Esma Yuca, Sinan Kopuzlu
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How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. [PDF]
, 2020 Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of
Croll, Tristan I +9 more
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Determinants of IGF-II influencing stability, receptor binding and activation
Scientific Reports, 2022 Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth +4 more
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Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B [PDF]
, 2013 Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity.
Barcos, Lucía Soledad +6 more
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Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II. [PDF]
PLoS ONE, 2011 BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function.
Clair L Alvino +6 more
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The receptor for insulin-like growth factor II mediates an insulin-like response. [PDF]
The EMBO Journal, 1987 Insulin-like growth factor II (IGF-II) shares sequence homology and predicted three-dimensional structure with insulin and IGF-I. IGF-II can bind, therefore, to a limited extent with the receptors for these two other hormones, as well as to a distinct receptor for IGF-II.
Joji Hari +5 more
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