Cellular Physiology and Biochemistry, 2018 Background/Aims: Islet beta cells (β-cells) are unique cells that play a critical role in glucose homeostasis by secreting insulin in response to increased glucose levels. Voltage-gated ion channels in β-cells, such as K+ and Ca2+ channels, contribute to
Chong Chen +10 more
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Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
, 2017 ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah +8 more
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Mesenchymal Stem Cell Therapy in Diabetes Mellitus: Progress and Challenges
Journal of Nucleic Acids, 2013 Advanced type 2 diabetes mellitus is associated with significant morbidity and mortality due to cardiovascular, nervous, and renal complications. Attempts to cure diabetes mellitus using islet transplantation have been successful in providing a source ...
Nagwa El-Badri, Mohamed A. Ghoneim
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Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]
, 2016 Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I. +3 more
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Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Nature Communications, 2019 Defective CFTR protein, responsible for Cystic Fibrosis (CF), is highly expressed in pancreatic ductal epithelial cells (PDECs) but their impact on insulin secreting pancreatic islets is not fully understood.
Kyu Shik Mun +10 more
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Indian Journal of Endocrinology and Metabolism, 2012 Background: Diabetics are incapable of producing insulin/have autoimmune mechanisms making it ineffective to control glucose secretion. We present a prospective study of glucose-sensitive insulin-secreting mesenchymal stem cells (IS-MSC) generated from ...
Shruti D Dave +2 more
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Molecular Therapy: Nucleic Acids, 2013 Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement strategy. We have developed
Vikash Reebye +9 more
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[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice [PDF]
, 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Akhter, Farjana +9 more
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How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?
Frontiers in Immunology, 2015 Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux +5 more
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Voltage‐activated Ca2+ currents in insulin‐secreting cells
FEBS Letters, 1985 Membrane voltage and voltage‐clamped membrane currents have been investigated with the whole‐cell patch clamp method in the insulin‐secreting cell line RINm5F. The mean resting membrane potential of RINm5F cells was found to be −52 mV. Overshooting spike potentials could be evoked by membrane depolarisation in the absence of a secretagogue.
Findlay, Ian, Dunne, Mark J.
openaire +2 more sources