Autophagy Involves in Differentiation of Insulin-Secreting Cells from Adipose Derived Stem Cells [PDF]
Cell Journal, 2021 Objective: Destruction of pancreatic beta-cells induces an insulin deficiency and causes type 1 diabetes. The role of autophagy in inducing insulin-secreting cells (ISCs) from adipose-derived mesenchymal stem cells (AMSCs) was investigated in the current
Mahmoud Hashemitabar +3 more
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Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro [PDF]
Stem Cell Research & Therapy, 2019 Background Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells.
Fei Chen +9 more
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The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells [PDF]
Journal of Tissue Engineering, 2019 A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit.
Gabriel Alexander Salg +8 more
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Replication confers β cell immaturity [PDF]
Nature Communications, 2018 Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation ...
Sapna Puri +9 more
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch [PDF]
Stem Cell Research & TherapyBackground Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges.
Mohammad Izadifar +8 more
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The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells. [PDF]
Front Pharmacol, 2019 Saponara S +7 more
europepmc +2 more sources
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa. [PDF]
Molecules, 2018 Demine S +14 more
europepmc +3 more sources
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. [PDF]
PLoS One, 2018 Panse M +8 more
europepmc +3 more sources
Biphasic voltage-dependent inactivation of human Na<sub>V</sub> 1.3, 1.6 and 1.7 Na<sup>+</sup> channels expressed in rodent insulin-secreting cells. [PDF]
J Physiol, 2018 Godazgar M +3 more
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ROCK1 regulates insulin secretion from β-cells [PDF]
Molecular Metabolism, 2021 ABSTRACTObjectiveThe endocrine pancreatic β-cells play a pivotal role in the maintenance of whole-body glucose homeostasis and its dysregulation is a consistent feature in all forms of diabetes. However, knowledge of intracellular regulators that modulate β-cell function remains incomplete.
Byung-Jun Sung +6 more
openaire +3 more sources