Results 11 to 20 of about 90,101 (333)
Replication confers β cell immaturity [PDF]
Nature Communications, 2018 Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation ...
Sapna Puri +9 more
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Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Vectorial insulin secretion by pancreatic β‐cells [PDF]
FEBS Letters, 1990 Morphological studies of pancreatic β‐cells have suggested the presence of discrete sensory and secretory domains. In the present study we now provide functional evidence by demonstrating polarity of insulin release by HIT‐T15 cells. A significant diffusion barrier across a twin chamber culture system was verified in the presence of confluent HIT‐T15 ...
Cortizo, Ana María +2 more
openaire +5 more sources
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. [PDF]
PLoS ONE, 2017 Glucagon-like peptide-1 (GLP-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes ...
Nunzia Caporarello +3 more
doaj +1 more source
Glucose represses connexin36 in insulin-secreting cells [PDF]
Journal of Cell Science, 2005 The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells. Glucose caused a significant reduction of Cx36 in insulin-secreting cell lines and freshly isolated pancreatic rat islets.
ALLAGNAT F +4 more
openaire +5 more sources
ROCK1 regulates insulin secretion from β-cells [PDF]
Molecular Metabolism, 2021 ABSTRACTObjectiveThe endocrine pancreatic β-cells play a pivotal role in the maintenance of whole-body glucose homeostasis and its dysregulation is a consistent feature in all forms of diabetes. However, knowledge of intracellular regulators that modulate β-cell function remains incomplete.
Byung-Jun Sung +6 more
openaire +4 more sources
Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
doaj +1 more source
Overcoming the Limitations of Stem Cell-Derived Beta Cells
Biomolecules, 2022 Great advances in type 1 diabetes (T1D) and type 2 diabetes (T2D) treatment have been made to this day. However, modern diabetes therapy based on insulin injections and cadaveric islets transplantation has many disadvantages.
Mariana V. Karimova +2 more
doaj +1 more source
Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. [PDF]
PLoS ONE, 2011 BACKGROUND:High fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase C delta (PKCδ) in β-cells.
Felicia Ranta +11 more
doaj +1 more source
Size-controlled insulin-secreting cell clusters [PDF]
Acta Biomaterialia, 2012 The search for an effective cure for type I diabetes from the transplantation of encapsulated pancreatic β-cell clusters has so far produced sub-optimal clinical outcomes. Previous efforts have not controlled the size of transplanted clusters, a parameter implicated in affecting long-term viability and the secretion of therapeutically sufficient ...
Tejal A. Desai +3 more
openaire +3 more sources