Results 21 to 30 of about 98,089 (330)
Spleen extracellular matrix provides a supportive microenvironment for β-cell function [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Type 1 diabetes mellitus is a common autoimmune and multifactorial disorder. Researchers have been interested in making a favorable islet-like tissue model for the treatment of diabetes. The main objective of this study was to determine the
Layasadat Khorsandi +5 more
doaj +1 more source
Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block [PDF]
Diabetes & Metabolism Journal, 2015 Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from α-cell has languished whereas β-cell taking center stage.
Jun Sung Moon, Kyu Chang Won
doaj +1 more source
TRPC3 Regulates Islet Beta‐Cell Insulin Secretion
Advanced Science, 2023 AbstractInsulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose‐stimulated insulin secretion (GSIS) is studied in human and animal islets.
Gaëlle Rached +8 more
openaire +4 more sources
Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins [PDF]
Journal of Biological Chemistry, 2003 Diabetes is associated with significant changes in plasma concentrations of lipoproteins. We tested the hypothesis that lipoproteins modulate the function and survival of insulin-secreting cells. We first detected the presence of several receptors that participate in the binding and processing of plasma lipoproteins and confirmed the internalization of
Marc-Estienne Roehrich +10 more
openalex +5 more sources
iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
doaj +1 more source
Size-controlled insulin-secreting cell clusters [PDF]
Acta Biomaterialia, 2012 The search for an effective cure for type I diabetes from the transplantation of encapsulated pancreatic β-cell clusters has so far produced sub-optimal clinical outcomes. Previous efforts have not controlled the size of transplanted clusters, a parameter implicated in affecting long-term viability and the secretion of therapeutically sufficient ...
Adam D, Mendelsohn +3 more
openaire +2 more sources
ABCA12 regulates insulin secretion from β‐cells [PDF]
EMBO reports, 2020 Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in regulating insulin secretion from β-cells. Mice with β-cell-specific deletion of Abca12 display impaired glucose-stimulated insulin secretion and eventual ...
Gloria M Ursino +18 more
openaire +3 more sources
Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination. [PDF]
PLoS ONE, 2013 Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated.
Eva Tudurí +5 more
doaj +1 more source
Vectorial insulin secretion by pancreatic β‐cells [PDF]
FEBS Letters, 1990 Morphological studies of pancreatic β‐cells have suggested the presence of discrete sensory and secretory domains. In the present study we now provide functional evidence by demonstrating polarity of insulin release by HIT‐T15 cells. A significant diffusion barrier across a twin chamber culture system was verified in the presence of confluent HIT‐T15 ...
Cortizo, Ana María +2 more
openaire +4 more sources
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. [PDF]
PLoS ONE, 2017 Glucagon-like peptide-1 (GLP-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes ...
Nunzia Caporarello +3 more
doaj +1 more source