Results 51 to 60 of about 94,888 (208)

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

Cell Therapy for Type 1 Diabetes [PDF]

, 2014
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher ...
Docherty, H. M., Docherty, K., Lima, M. J., Muir, K. R.   +3 more
core   +1 more source

Developmental and functional effects of steroid hormones on the neuroendocrine axis and spinal cord [PDF]

, 2016
This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual ...
Gonzalez Deniselle, Maria Claudia, Lara, H. E., Recabarren, S. E., Roselli, C. E., Zubeldia Brenner, Lautaro   +4 more
core   +2 more sources

TRPM4 controls insulin secretion in pancreatic β-cells [PDF]

Cell Calcium, 2007
TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and proposed to be involved in cell depolarization. In excitable cells, TRPM4 may regulate calcium influx by causing the depolarization that drives the activation of voltage-dependent calcium channels.
Henrique, Cheng, Andreas, Beck, Pierre, Launay, Stefan A, Gross, Alexander J, Stokes, Jean-Pierre, Kinet, Andrea, Fleig, Reinhold, Penner   +7 more
openaire   +2 more sources

In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications

Journal of Diabetes Research, 2016
β-Cell replacement through transplantation is the only curative treatment to establish a long-term stable euglycemia in diabetic patients. Owing to the shortage of donor tissue, attempts are being made to develop alternative sources of insulin-secreting ...
Guoguang Niu, John P. McQuilling, Yu Zhou, Emmanuel C. Opara, Giuseppe Orlando, Shay Soker   +5 more
doaj   +1 more source

β-Cell Mitochondria and Insulin Secretion

Diabetes, 2002
The β-cell mitochondria are known to generate metabolic coupling factors, or messengers, that mediate plasma membrane depolarization and the increase in cytosolic Ca2+, the triggering event in glucose-stimulated insulin secretion. Accordingly, ATP closes nucleotide-sensitive K+ channels necessary for the opening of voltage-gated Ca2+ channels. ATP also
Claes B. Wollheim, Pierre Maechler
openaire   +2 more sources

Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis.

PLoS ONE, 2016
It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion.
Changhwan Ahn, Dongoh Lee, Jae-Hwan Lee, Hyun Yang, Beum-Soo An, Eui-Bae Jeung   +5 more
doaj   +1 more source

Pasireotide for the Medical Management of Feline Hypersomatotropism [PDF]

, 2015
BACKGROUND: Feline hypersomatotropism (HST) is a cause of diabetes mellitus in cats. Pasireotide is a novel multireceptor ligand somatostatin analog that improves biochemical control of humans with HST.
Abraham, Adams, Alt, Appleton, Bhayana, Bruns, Castillo, Church, Colao, Colao, Cuevas-Ramos, Fedele, Fernandez-Rodriguez, Fougner, Golor, Henry, Hofland, Juul, Katznelson, Kvols, Lamb, Lamberts, Maxwell, Meij, Miller, Murray, Myers, Niessen, Niessen, Niessen, Niessen, Petrus, Polska, Rand, Ray, Schmid, Schmid, Sheppard, Slingerland, Sohmiya, Starkey, Stolk, Taboada, Wajchenberg, Zatelli, Zou   +45 more
core   +2 more sources

Vildagliptin Enhances Differentiation of Insulin Producing Cells from Adipose-Derived Mesenchymal Stem Cells

Cell Journal, 2018
Objective: Type 1 diabetes is caused by destruction of beta cells of pancreas. Vildagliptin (VG), a dipeptidyl peptidase IV (DPP IV) inhibitor, is an anti-diabetic drug, which increases beta cell mass.
Samaneh Karimi, Jafar Ai, Layasadat Khorsandi, Darioush Bijan Nejad, Ghasem Saki   +4 more
doaj   +1 more source

Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells. [PDF]

PLoS ONE, 2013
β-cell replacement may efficiently cure type 1 diabetic (T1D) patients whose insulin-secreting β-cells have been selectively destroyed by autoantigen-reactive T cells.
Anujith Kumar, Antonio Lo Nigro, Conny Gysemans, Qing Cai, Camila Esguerra, Molly Nelson-Holte, Yves Heremans, María Jiménez-González, Angelo Porciuncula, Chantal Mathieu, Bert Binas, Harry Heimberg, Felipe Prosper, Bernhard Hering, Catherine M Verfaillie, Miguel Barajas   +15 more
doaj   +1 more source