Results 51 to 60 of about 98,089 (330)

The Combined Expression of and with Either or Improves the Differentiation Efficiency of Mouse Embryonic Stem Cells into Insulin-Producing Cells

Cell Transplantation, 2013
The use of pancreatic β-cells differentiated from embryonic stem (ES) cells or induced pluripotent stem (iPS) cells is a promising strategy in cell therapy. Pancreatic β-cell development is regulated by the sequential expression of a molecular network of
Huiming Xu, Kam Sze Tsang, Juliana C. N. Chan, Ping Yuan, Rongrong Fan, Hideaki Kaneto, Gang Xu   +6 more
doaj   +1 more source

Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

BMC Genomics, 2021
Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened ...
Daniel Oropeza, Valentina Cigliola, Agustín Romero, Simona Chera, Santiago A. Rodríguez-Seguí, Pedro L. Herrera   +5 more
doaj   +1 more source

Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type 1 Diabetic Mice without Immunosuppression

Cell Transplantation, 2012
In the present study, we examined the therapeutic potential of human amnion-derived insulin-secreting cells for type 1 diabetes. Human amniotic mesenchymal stem cells (hAMs) were isolated from amnion and cultivated to differentiate into insulin-secreting
J. Kim, S. Park, H. M. Kang, C. W. Ahn, H. C. Kwon, J. H. Song, Y. J. Lee, K. H. Lee, H. Yang, S. Y. Baek, S. H. Yoo, S. H. Kim, H. Kim   +12 more
doaj   +1 more source

Islet formation during the neonatal development in mice. [PDF]

PLoS ONE, 2009
The islet of Langerhans is a unique micro-organ within the exocrine pancreas, which is composed of insulin-secreting beta-cells, glucagon-secreting alpha-cells, somatostatin-secreting delta-cells, pancreatic polypeptide-secreting PP cells and ghrelin ...
Kevin Miller, Abraham Kim, German Kilimnik, Junghyo Jo, Uchenna Moka, Vipul Periwal, Manami Hara   +6 more
doaj   +1 more source

Differentiation of Endogenous Bone Marrow-Derived Cells into Insulin-Producing Cells Using Four Soluble Factors [PDF]

Diabetes & Metabolism Journal
Four soluble factors—putrescine, glucosamine, nicotinamide, and signal transducer and activator of transcription 3 (STAT3) inhibitor BP-1-102—were shown to differentiate bone marrow mononucleated cells (BMNCs) into functional insulin-producing cells ...
Seung-Ah Lee, Subin Kim, Seog-Young Kim, Jong Yoen Park, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park   +6 more
doaj   +1 more source

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Nature Communications, 2022
In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP ...
Jolanta Chmielowiec, Wojciech J. Szlachcic, Diane Yang, Marissa A. Scavuzzo, Katrina Wamble, Alejandro Sarrion-Perdigones, Omaima M. Sabek, Koen J. T. Venken, Malgorzata Borowiak   +8 more
doaj   +1 more source

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

Frontiers in Immunology, 2021
To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse.
Sandrine Luce, Sandrine Luce, Sophie Guinoiseau, Sophie Guinoiseau, Alexis Gadault, Alexis Gadault, Franck Letourneur, Patrick Nitschke, Marc Bras, Michel Vidaud, Pierre Charneau, Etienne Larger, Etienne Larger, Maikel L. Colli, Decio L. Eizirik, Decio L. Eizirik, François Lemonnier, François Lemonnier, Christian Boitard, Christian Boitard, Christian Boitard   +20 more
doaj   +1 more source

Parathyroid localization [PDF]

, 1986
Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH.
Borisch, B., Gutekunst, R., Hafermann, W., Kiffner, E., Löhrs, U., Scriba, Peter Christian, Thies, E., Valesky, A.   +7 more
core   +1 more source

The Cell Physiology of Biphasic Insulin Secretion

Physiology, 2000
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.
Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S   +5 more
openaire   +3 more sources

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells [PDF]

Endocrinology and Metabolism, 2015
BackgroundDamaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells.
Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Min Kyeong Kim, Jung Hee Kim, Masaaki Komatsu, Keiji Tanaka, Hakmo Lee, Sung Soo Chung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung   +12 more
doaj   +1 more source