Results 91 to 100 of about 4,110,467 (359)

Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms [PDF]

, 2021
Zeng-Hui Wei, Jagadish Koya, Sandra E. Reznik   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

FEBS Open Bio
Glucose homeostasis is maintained by insulin. Insulin resistance is caused by multiple factors including hereditary factors and diet. The molecular mechanism underlying insulin resistance (IR) is not completely understood. Hyperinsulinemia often precedes
Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri   +6 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation

Frontiers in Pharmacology, 2020
Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild ...
Xiaomei Zou, Xiyao Feng, Yalin Fu, Yalin Fu, Yuyang Zheng, Yuyang Zheng, Mingke Ma, Mingke Ma, Changhua Wang, Changhua Wang, Yemin Zhang, Yemin Zhang   +11 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Prevalence of insulin resistance in chronic hepatitis C genotype 1 and 3 patients

Annals of Hepatology, 2013
Background and rationale. Chronic infection with the hepatitis C virus (HCV) is associated with a higher prevalence of insulin resistance compared to the general population.
Décio Passos Sampaio Péres, Hugo Cheinquer, Fernando Herz Wolf, Nelson Cheinquer, Maicon Falavigna, Luciana Dornelles Sampaio Péres   +5 more
doaj   +1 more source

Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients [PDF]

, 2022
Lourdes Balcázar‐Hernández, Victoria Mendoza‐Zubieta, Baldomero González‐Virla, Brenda González-García, Mariana Osorio-Olvera, Jesús Ubaldo Peñaloza-Juárez, Irene Irisson-Mora, Martha Cruz-López, Raúl Rodríguez-Gómez, Ramón Espinoza-Pérez, Guadalupe Vargas‐Ortega   +10 more
openalex   +1 more source

Insulin resistance syndrome.

Nihon Naika Gakkai Zasshi, 1996
ある一定濃度のインスリンの存在下で,正常に発揮されるインスリン効果がみられない状態がインスリン抵抗性である.当初は,肥満者やインスリン非依存性糖尿病患者等,ある特殊な病態にみられる変化と考えられていたが,最近になって,想像された以上に多くの疾患がこの病態に関与していることが明らかとなった.さらにインスリン抵抗性を基礎病変として,糖代謝異常のほか,高脂血症,高血圧,血液凝固系の異常等の諸変化をきたし,動脈硬化の進展から,脳・心血管系疾患の発症に密接に関与する病態として注目されるようになった.このような諸病態を総括する名称としてsyndrome X, deadly quartet,あるいは本稿のテーマとなっているインスリン抵抗性症侯群等が提唱されている.さらにこのような病態を呈するものでは ...
openaire   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source