Results 91 to 100 of about 930,240 (308)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation

Frontiers in Pharmacology, 2020
Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild ...
Xiaomei Zou, Xiyao Feng, Yalin Fu, Yalin Fu, Yuyang Zheng, Yuyang Zheng, Mingke Ma, Mingke Ma, Changhua Wang, Changhua Wang, Yemin Zhang, Yemin Zhang   +11 more
doaj   +1 more source

TyG index and insulin resistance in beta-thalassemia [PDF]

, 2015
Insulin resistance (IR) underlies some glucose metabolism abnormalities in thalassemia major. Recently, triglyceride glucose index (TyG) has been proposed for evaluating insulin resistance as a simple, low cost, and accessible tool.
Fayaz, M., Hosseini, S.M., Jamshir, M., Mirbehbahani, N.   +3 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells

Physiological Reports
Endurance‐oriented exercise typically enhances insulin action in skeletal muscle; however, relatively little is known about the impact of resistance exercise. In the present study, insulin action was determined in primary human skeletal muscle stem cells
Polina Krassovskaia, Filip Jevtovic, Donghai Zheng, John Noone, Reichelle X. Yeo, Maria F. Pino, Cynthia L. Stowe, Shannon S. Emilson, Nicolas Musi, Kim M. Huffman, Caitlin Hebert, Sophia Bowen, Simona Zarini, Eric Ravussin, Nicholas T. Broskey, William E. Krauss, Bryan C. Bergman, Lauren M. Sparks, Joseph A. Houmard   +18 more
doaj   +1 more source

Insulin Resistance: From Theory To Practice [PDF]

, 2006
Insulin resistance is at the core of the well recognised metabolic syndrome and possibly many other ailments commonly seen in the modern society. While the quantification of insulin resistance remains a difficult task, the problems associated with it are
Kakkilaya Bevinje, Dr. Srinivas
core   +1 more source

Insulin resistance syndrome.

Nihon Naika Gakkai Zasshi, 1996
ある一定濃度のインスリンの存在下で,正常に発揮されるインスリン効果がみられない状態がインスリン抵抗性である.当初は,肥満者やインスリン非依存性糖尿病患者等,ある特殊な病態にみられる変化と考えられていたが,最近になって,想像された以上に多くの疾患がこの病態に関与していることが明らかとなった.さらにインスリン抵抗性を基礎病変として,糖代謝異常のほか,高脂血症,高血圧,血液凝固系の異常等の諸変化をきたし,動脈硬化の進展から,脳・心血管系疾患の発症に密接に関与する病態として注目されるようになった.このような諸病態を総括する名称としてsyndrome X, deadly quartet,あるいは本稿のテーマとなっているインスリン抵抗性症侯群等が提唱されている.さらにこのような病態を呈するものでは ...
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System

Biomedicines
Hyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily, Ashley Jazzar, Amira Abou-Aichi, Danielle Jacques   +3 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source