Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Frontiers in Physiology, 2020 Obesity is one of the major health burdens of the 21st century as it contributes to the growing prevalence of its related comorbidities, including insulin resistance and type 2 diabetes.
Federica Zatterale +6 more
semanticscholar +1 more source
Mechanisms of Insulin Action and Insulin Resistance.
Physiological Reviews, 2018 The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matured, coalescing into solid and fertile ground for ...
Max C. Petersen, G. Shulman
semanticscholar +1 more source
Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents [PDF]
, 2018 OBJECTIVE: To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of insulin ...
Dimeglio, Linda A. +13 more
core +1 more source
Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? [PDF]
, 2015 Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging.
LaBarge, Samuel +2 more
core +2 more sources
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Insulin and Insulin Resistance in Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose production.
Aleksandra Sędzikowska, L. Szablewski
semanticscholar +1 more source
The prevalence of the metabolic syndrome in Portugal: the PORMETS study
BMC Public Health, 2017 Background The PORMETS study was designed to estimate the prevalence of metabolic syndrome and its determinants in the overall and administrative regions of the Portuguese mainland.
Luís Raposo +3 more
doaj +1 more source
Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome [PDF]
, 2013 Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient.
Bonin, Cecilia +12 more
core +1 more source
Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance
Inflammation, 2021 Obesity, manifested by increased adiposity, represents a main cause of morbidity in the developed countries, causing increased risk of insulin resistance and type 2 diabetes mellitus. Recruitment of macrophages and activation of innate immunity represent
Layla Al-mansoori +3 more
semanticscholar +1 more source