Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]
, 2016 Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco +12 more
core +1 more source
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]
, 2019 Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi +12 more
core +1 more source
Analysis of factors associated with insulin resistance in young women: A cross-sectional study
Clinical Nutrition Open Science, 2023 Summary: Background & aims: Impaired glucose tolerance in young women may lead to the future development of gestational diabetes mellitus and/or type 2 diabetes mellitus.
Isaki Hanamura +6 more
doaj +1 more source
Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]
, 2009 <b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C. +8 more
core +1 more source
Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]
, 2012 Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun +6 more
core +1 more source
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]
, 2017 Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I +8 more
core +1 more source
Inflammation and insulin resistance [PDF]
Journal of Clinical Investigation, 2006 Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until ...
Allison B. Goldfine +2 more
openaire +4 more sources
Sirtuins and Insulin Resistance [PDF]
Frontiers in Endocrinology, 2018 The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence, metabolism and genome stability.
Hou-Zao Chen +2 more
openaire +4 more sources
Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal: potential glucogenic role for GLP-1. [PDF]
, 2013 Prolonged food deprivation increases lipid oxidation and utilization, which may contribute to the onset of the insulin resistance associated with fasting.
Crocker, Daniel E +7 more
core +1 more source