Results 31 to 40 of about 3,853,066 (390)
Comparative Analysis of Kinetic Realizations of Insulin Signaling [PDF]
arXiv, 2023 Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the human body's main source of energy. Fortunately, reaction network analysis allows us to extract properties of dynamical systems without depending on their model parameter ...
arxiv
TLR4 and Insulin Resistance [PDF]
Gastroenterology Research and Practice, 2010 Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary
Jane J. Kim, Dorothy D. Sears
openaire +4 more sources
Machine learning for the diagnosis of early stage diabetes using temporal glucose profiles [PDF]
, 2020 Machine learning shows remarkable success for recognizing patterns in data. Here we apply the machine learning (ML) for the diagnosis of early stage diabetes, which is known as a challenging task in medicine. Blood glucose levels are tightly regulated by two counter-regulatory hormones, insulin and glucagon, and the failure of the glucose homeostasis ...
arxiv +1 more source
The Relationship Between Insulin Resistance Neutrophil to Lymphocyte Ratio [PDF]
arXiv, 2022 Aim: There is increasing interest in the role of chronic inflammation on pathogenesis of various disease, and one of its markers, high NLR is associated with various mortality and morbidity risk. Insulin resistance (IR) might be one potential associate factors, as suggested in preclinical studies.
arxiv
TLR4 links innate immunity and fatty acid-induced insulin resistance.
Journal of Clinical Investigation, 2006 TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types.
Hang Shi +5 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2020 The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also associated with variable cardiometabolic diseases such as cardiovascular ...
So-hyeon Hong, K. Choi
semanticscholar +1 more source
BMC Women's Health, 2023 Objective In this study, patients were divided into two groups. Patients with polycystic ovary syndrome (PCOS) and patients with polycystic ovary syndrome + Hashimoto's Thyroid (PCOS + HT).
Gülcan Gencer +2 more
doaj +1 more source
Fructose and hepatic insulin resistance
Critical reviews in clinical laboratory sciences, 2020 Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance.
S. Softic +8 more
semanticscholar +1 more source
Inflammation and insulin resistance [PDF]
Journal of Clinical Investigation, 2006 Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until ...
Allison B. Goldfine +2 more
openaire +4 more sources
Sirtuins and Insulin Resistance [PDF]
Frontiers in Endocrinology, 2018 The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence, metabolism and genome stability.
Hou-Zao Chen +2 more
openaire +4 more sources