Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals. a cross-sectional study [PDF]
, 2018 .Preclinical studies suggested that IgG2c isotype may specifically impair skeletal muscle insulin sensitivity in mice. In this study we investigated the association between serum levels of the four IgG subclasses and insulin sensitivity in non-diabetic
Andreozzi, F +11 more
core +2 more sources
Metabolic Inflammation and Insulin Resistance in Obesity
Circulation Research, 2020 Supplemental Digital Content is available in the text. Obesity is becoming an epidemic in the United States and worldwide and increases risk for many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular disease.
Huaizhu Wu, C. Ballantyne
semanticscholar +1 more source
Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]
, 2016 Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco +12 more
core +1 more source
Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020 Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of ...
Yohannes Tsegyie Wondmkun
semanticscholar +1 more source
Insulin Signal Transduction Perturbations in Insulin Resistance
International Journal of Molecular Sciences, 2021 Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood glucose and inadequate insulin action, which leads to insulin resistance.
Mariyam Khalid +3 more
semanticscholar +1 more source
Post-operative insulin resistance
Сахарный диабет, 2017 Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear.
Irina Aleksandrovna Tarasova +2 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Noncommunicable diseases (NCDs), such as diabetes and related neurological disorders, are considered to not be directly transmissible from one person to another. However, NCDs may be transmissible in vivo through extracellular vesicles (EVs). A long-term
Biao Li +3 more
doaj +1 more source
Insulin resistance in type 1 diabetes: what is ‘double diabetes’ and what are the risks? [PDF]
, 2013 In this review, we explore the concept of ‘double diabetes’, a combination of type 1 diabetes with features of insulin resistance and type 2 diabetes.
A Caixas +62 more
core +3 more sources
Association between insulin resistance and the development of cardiovascular disease
Cardiovascular Diabetology, 2018 For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
V. Ormazábal +5 more
semanticscholar +1 more source
Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance
Nutrients, 2020 Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. The exact mechanism by which adipose tissue induces insulin resistance is still unclear.
Iwona Kojta +2 more
semanticscholar +1 more source