Results 211 to 220 of about 307,626 (315)

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis. [PDF]

Stem Cell Res Ther
Gao J, Li B, Tian H, Li C, Merzlikin N, Han D, Ling Z, Zhang Z, Zhu W, Dai J, Gerunova L, Lv C, Li N, Hua J.   +13 more
europepmc   +1 more source

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne Jackson, Vasudha Ahuja, Stefan R Bornstein, Laura J. Corbin, Graciela Delgado, Om Prakash Dwivedi, Lilian Fernandes Silva, Timothy M Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra M. Herrmann, Kurt Højlund, David A. Hughes, Marcus E. Kleber, C M Lindgren, Ching‐Ti Liu, Jian'an Luan, Anni Malmberg, Angela P. Moissl, Andrew P Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E. H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Jaakko Tuomilehto, Andrew R. Wood, Peitao Wu, Björn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, José C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Debbie A. Lawlor, Lars Lind, Winfried März, James B. Meigs, Johan Sundström, Nicholas J. Timpson, Róbert Wágner, Mark Walker, Nicholas J Wareham, Hugh Watkins, Inês Barroso, Stephen O’Rahilly, Niels Grarup, Stephen C.J. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke   +70 more
openalex   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Estimating homeostasis model assessment for insulin secretion by using multiple adaptive regression spline in healthy Taiwanese men. [PDF]

Sci Rep
Ma CH, Yeh PT, Yang CC, Pei D, Chu TW, Liang YJ.   +5 more
europepmc   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Cyclic-imide derivative (5e) attenuates hyperglycemia in type 1 diabetic rats by protecting pancreatic cells and enhancing insulin secretion. [PDF]

Saudi Pharm J
Alanazi WA, Alenezi AH, El-Nagar DM, Alanazi MM, Almutairi MM, Abdel-Aziz AA, El-Azab AS.   +6 more
europepmc   +1 more source

Serotonin Receptor 2C and Insulin Secretion

, 2013
Qiang Zhang, Yunxia Zhu, Wenbo Zhou, Lu Gao, Yuan Li, Xiao Han   +5 more
openalex   +2 more sources

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion. [PDF]

J Biol Chem
Zhou Y, Baez N, Fu T, Brun T, Maechler P.   +4 more
europepmc   +1 more source