Results 1 to 10 of about 154,422 (243)
Blood, 2020 BACKGROUND: Follicular lymphoma (FL) is an indolent malignancy of germinal center B-cell origin. FL patients experience remarkable heterogeneity in their disease trajectory, with many patients slowly progressing over several years, and a subset of patients experiencing an aggressive clinical course.
Maria Tsiper +33 more
openaire +3 more sources
Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
iScience, 2023 Summary: G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma membrane signaling proteins. However, virtually nothing is known about their recruitment to COPII vesicles for forward delivery after synthesis in the endoplasmic ...
Xin Xu, Nevin A. Lambert, Guangyu Wu
doaj +1 more source
Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate
iScience, 2021 Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer ...
Liang Guo +8 more
doaj +1 more source
A fatal affair: Circulating tumor cell relationships that shape metastasis
iScience, 2021 Summary: Circulating tumor cells are metastatic precursors in several cancer types. Their biology and clinical utility are subject to numerous investigations, yet one aspect that is often neglected is their entanglement with the tumor microenvironment ...
Lauren L. Ozimski +2 more
doaj +1 more source
Contribution of septins to human platelet structure and function
iScience, 2022 Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim +5 more
doaj +1 more source
Glycosylation network mapping and site-specific glycan maturation in vivo
iScience, 2022 Summary: Glycoprotein processing along a complex highly compartmentalized pathway is a hallmark of eukaryotic cells. We followed the kinetics of intracellular, site-specific glycan processing of a model protein with five distinct N-glycosylation sites ...
Marie-Estelle Losfeld +3 more
doaj +1 more source
iScience, 2023 Summary: The Epithelial-to-Mesenchymal Transition (EMT) is a hallmark of cancer metastasis and morbidity. EMT is a non-binary process, and cells can be stably arrested en route to EMT in an intermediate hybrid state associated with enhanced tumor ...
Annice Najafi +2 more
doaj +1 more source
Identification of lysine-lactylated substrates in gastric cancer cells
iScience, 2022 Summary: Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM)
Dawei Yang +5 more
doaj +1 more source
iScience, 2021 Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina +3 more
doaj +1 more source
An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli. [PDF]
, 2014 Given the vast behavioral repertoire and biological complexity of even the simplest organisms, accurately predicting phenotypes in novel environments and unveiling their biological organization is a challenging endeavor.
Carrera, Javier +5 more
core +1 more source