Results 31 to 40 of about 154,422 (243)

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

STAT3 drives the expression of ACSL4 in acute kidney injury

iScience
Summary: Long-chain acyl-CoA synthetase family 4 (ACSL4) metabolizes long-chain polyunsaturated fatty acids (PUFAs), enriching cell membranes with phospholipids susceptible to peroxidation and drive ferroptosis.
Virginie Poindessous, Helene Lazareth, Gilles Crambert, Lydie Cheval, Julio L. Sampaio, Nicolas Pallet   +5 more
doaj   +1 more source

Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell-derived hepatic organoids

iScience, 2023
Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses ...
Jong-Hwan Kim, Seon Ju Mun, Jeong-Hwan Kim, Myung Jin Son, Seon-Young Kim   +4 more
doaj   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

An integrative analysis of cancer gene expression studies using Bayesian latent factor modeling

, 2010
We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies.
Chen, Julia Ling-Yu, Chi, Jen-Tsan, Merl, Daniel, West, Mike   +3 more
core   +1 more source

An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems [PDF]

, 2014
The authors would like to thank the support on this research by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer ...
Coghill, George M, Pang, Wei, Wu, Zujian
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Primary and metastatic cellular landscapes in human pancreatic cancer

iScience
Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a complex tumor microenvironment (TME). We utilized single cell RNA sequencing to compare the TMEs of metastatic sites and primary tumors.
Nina G. Steele, Veerin R. Sirihorachai, Ahmed M. Elhossiny, Ian M. Loveless, Padma Kadiyala, Monica Bonilla, Emily L. Lasse-Opsahl, Carinna Solano Vargas, Katelyn L. Donahue, Samantha B. Kemp, Valerie Gunchick, Yatrik M. Shah, Timothy L. Frankel, Filip Bednar, Arvind Rao, Benjamin L. Allen, Jiaqi Shi, Vaibhav Sahai, Howard C. Crawford, Eileen S. Carpenter, Marina Pasca di Magliano   +20 more
doaj   +1 more source

Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation

iScience, 2020
Summary: Although the dynamic features of type I coherent feedforward loop (C1-FFL) has been well studied, how C1-FFL shapes cell-to-cell heterogeneity remains unclear.
Jie Zhou, Tingzhe Sun, Shouheng Jin, Zhiyong Guo, Jun Cui   +4 more
doaj   +1 more source