Results 51 to 60 of about 161,935 (259)

An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems [PDF]

, 2014
The authors would like to thank the support on this research by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer ...
Coghill, George M, Pang, Wei, Wu, Zujian
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

DNA-damage-associated protein co-expression network in cardiomyocytes informs on tolerance to genetic variation and disease

iScience
Summary: Cardiovascular disease (CVD) is associated with genetic variants and environmental factors. A consequence of multiple risk factors is DNA damage.
Omar Darrel Johnson, Sayan Paul, José Angel Gutiérrez, William Kent Russell, Michelle Claire Ward   +4 more
doaj   +1 more source

Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq

iScience, 2019
Summary: We perform a single-cell RNA sequencing analysis to investigate the phenotypic and functional heterogeneity of the adult mouse prostate stromal cells.
Oh-Joon Kwon, Yiqun Zhang, Yumei Li, Xing Wei, Li Zhang, Rui Chen, Chad J. Creighton, Li Xin   +7 more
doaj   +1 more source

How neurons maintain their axons long-term: an integrated view of axon biology and pathology

Frontiers in Neuroscience, 2023
Axons are processes of neurons, up to a metre long, that form the essential biological cables wiring nervous systems. They must survive, often far away from their cell bodies and up to a century in humans.
Gaynor Smith, Sean T. Sweeney, Cahir J. O’Kane, Andreas Prokop   +3 more
doaj   +1 more source

Archiving and disseminating integrative structure models. [PDF]

, 2019
Limitations in the applicability, accuracy, and precision of individual structure characterization methods can sometimes be overcome via an integrative modeling approach that relies on information from all available sources, including all available ...
Berman, Helen M, Sali, Andrej, Vallat, Brinda, Webb, Benjamin, Westbrook, John   +4 more
core  

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells

iScience
Summary: Acyl-CoA synthetase long-chain family (ACSL) enzymes are critical in the activation of long-chain fatty acid. To determine the regulatory mechanisms of ACSL5 and its biological functions within the kidney tubule, we generated transcriptomic ...
Virginie Poindessous, Julio L. Sampaio, Lydia Bouidghaghen, Ivan Nemazanyy, Alexandre Pallet, Maarten Naesens, Thibaut Vaulet, Dany Anglicheau, Nicolas Pallet   +8 more
doaj   +1 more source

Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology

Frontiers in Immunology, 2021
The scopes related to the interplay between stem cells and the immune system are broad and range from the basic understanding of organism’s physiology and ecology to translational studies, further contributing to (eco)toxicology, biotechnology, and ...
Loriano Ballarin, Arzu Karahan, Alessandra Salvetti, Leonardo Rossi, Lucia Manni, Baruch Rinkevich, Amalia Rosner, Ayelet Voskoboynik, Ayelet Voskoboynik, Ayelet Voskoboynik, Benyamin Rosental, Laura Canesi, Chiara Anselmi, Chiara Anselmi, Annalisa Pinsino, Begüm Ece Tohumcu, Anita Jemec Kokalj, Andraž Dolar, Sara Novak, Michela Sugni, Ilaria Corsi, Damjana Drobne   +21 more
doaj   +1 more source