Results 71 to 80 of about 161,935 (259)

The genomes of two key bumblebee species with primitive eusocial organization [PDF]

, 2015
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies.
Amdam, Gro V., Antonio, David S. Marco, Aqrawi, Peshtewani K., Asher, Claire, Barribeau, Seth M., Beckers, Matthew, Bennett, Anna K., Beye, Martin, Biewer, Matthias, Bitondi, Márcia M. G., Blankenburg, Kerstin P., Blaxter, Mark L., Bloch, Guy, Blommaert, Julie, Bornberg-Bauer, Erich, Bourke, Andrew F. G., Brown, Mark J. F., Buechel, Severine D., Cameron, Rossanah, Cappelle, Kaat, Carolan, James C., Chipman, Ariel D., Chittka, Lars, Christiaens, Olivier, Ciborowski, Kate L., Clarke, David F., Colgan, Thomas J., Collins, David H., Coyle, Marcus, Cridge, Andrew G., Câmara, Francisco, Dalmay, Tamas, de Graaf, Dirk C., Dearden, Peter, Debyser, Griet, Devreese, Bart, Dreier, Stephanie, du Plessis, Louis, Duncan, Elizabeth, Elsik, Christine G., Erler, Silvio, Evans, Jay, Falcon, Tiago, Flores, Kevin, Fouks, Bertrand, Francisco, Liezl, Freitas, Flávia C. P., Fuchikawa, Taro, Gadau, Jürgen, Gempe, Tanja, Gibbs, Richard A., Grimmelikhuijzen, Cornelis J. P., Guigó, Roderic, Hartfelder, Klaus, Hasselmann, Martin, Hauser, Frank, Helbing, Sophie, Hernandez, Alvaro G., Hoff, Katharina, Holder, Michael, Hudson, Matthew E., Humann, Fernanda C., Irvine, Frano, Jackson, Laronda, Jayaseelan, Joy, Jermiin, Lars S., Johnson, Claire E., Johnson, Reed M., Jones, Andrew K., Joshi, Vandita, Kadowaki, Tatsuhiko, Kidner, Jonathan H., Klasberg, Steffen, Koch, Vasco, Kovar, Christie, Kraus, F Bernhard, Köhler, Arian, Lattorff, H. Michael G., Leask, Megan, Lee, Sandra L., Liu, Jisheng, Lockett, Gabrielle A., Lozier, Jeffrey D., Mallon, Eamonn B., Mariotti, Marco, Marxer, Monika, Mata, Robert, Mathew, Tittu, Meeus, Ivan, Moritz, Robin F. A., Munoz-Torres, Monica, Murphy, Terence, Muzny, Donna M., Nair, Ajay, Newsham, Irene F., Ngo, Robin, Nissen, Inga, Niu, Jinzhi, Nunes, Francis M. F., Näpflin, Kathrin, O'Neill, Meaghan P., Oakeshott, John G., Okwuonu, Geoffrey, Osborne, Amy, Otte, Marianne, Pham, Christopher, Pinheiro, Daniel G., Pu, Ling-Ling, Puiu, Daniela, Qu, Jiaxin, Richards, Stephen, Robertson, Hugh M., Robinson, Gene E., Rossié, Nina, Rueppell, Olav, Saada, Nehad, Sadd, Ben M., Salzberg, Steven L., Santesmasses, Didac, Santibanez, Jireh, Santos, Carolina G., Scherer, Steven E., Schmid-Hempel, Paul, Schmid-Hempel, Regula, Schmitt, Björn D., Schulte, Christina, Simmons, Denard, Simões, Zilá Lp, Smagghe, Guy, Soares, Michelle P. M., Stolle, Eckart, Sumner, Seirian, Swevers, Luc, Thornton, Rebecca, van Vaerenbergh, Matthias, Venkat, Aarti, Walden, Kimberly K. O., Waterhouse, Robert M., Winnebeck, Eva C., Wolschin, Florian, Worley, Kim C., Wu, Yuan-Qing, Yu, Na, Zdobnov, Evgeny M.   +143 more
core   +16 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Principles And Practices Fostering Inclusive Excellence: Lessons From The Howard Hughes Medical Institute’s Capstone Institutions [PDF]

, 2016
Best-practices pedagogy in science, technology, engineering, and mathematics (STEM) aims for inclusive excellence that fosters student persistence. This paper describes principles of inclusivity across 11 primarily undergraduate institutions designated ...
Cooke, D. B., III, Davidson, C., Davis, G. K., DiBartolo, P. M., Gregg-Jolly, L., Gross, D., Hertz, P. E., Hibbard, L., Ireland, S. K., Iverson, E., Mader, C., Manduca, C. A., Pai, A., Raps, S., Siwicki, Kathleen King, Swartz, J. E.   +15 more
core   +6 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells

iScience
Summary: Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV infection
Yuling Sun, Huidi Yu, Zhihao Zhan, Wei Liu, Penggang Liu, Jing Sun, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu   +9 more
doaj   +1 more source

Genome Architecture Mediates Transcriptional Control of Human Myogenic Reprogramming

iScience, 2018
Summary: Genome architecture has emerged as a critical element of transcriptional regulation, although its role in the control of cell identity is not well understood.
Sijia Liu, Haiming Chen, Scott Ronquist, Laura Seaman, Nicholas Ceglia, Walter Meixner, Pin-Yu Chen, Gerald Higgins, Pierre Baldi, Steve Smale, Alfred Hero, Lindsey A. Muir, Indika Rajapakse   +12 more
doaj   +1 more source

Systems analysis of host-parasite interactions. [PDF]

, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema, Lewis, Nathan E, Swann, Justine, Winzeler, Elizabeth A   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne muscular dystrophy

iScience
Summary: In Duchenne muscular dystrophy (DMD), muscle stem cells’ (MuSCs) regenerative capacities are overwhelmed leading to fibrosis. Whether MuSCs have intrinsic defects or are disrupted by their environment is unclear.
Jimmy Massenet, Michèle Weiss-Gayet, Hina Bandukwala, Wilhelm Bouchereau, Stéphanie Gobert, Mélanie Magnan, Arnaud Hubas, Patrick Nusbaum, Isabelle Desguerre, Cyril Gitiaux, F. Jeffrey Dilworth, Bénédicte Chazaud   +11 more
doaj   +1 more source