Results 81 to 90 of about 154,422 (243)

Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma

iScience
Summary: Genomic studies have identified oncogenic drivers in lung cancer, enabling effective targeted therapies. However, patients who initially respond inevitably experience regrowth.
Yang Tian, Reshmee Bhattacharya, Seungyeul Yoo, Feng Jiang, Eric Park, Genesis Lara Granados, Yudao Shen, Kwang-Su Park, Husnu Umit Kaniskan, Jian Jin, Benjamin D. Hopkins, Jun Zhu, Hideo Watanabe   +12 more
doaj   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne muscular dystrophy

iScience
Summary: In Duchenne muscular dystrophy (DMD), muscle stem cells’ (MuSCs) regenerative capacities are overwhelmed leading to fibrosis. Whether MuSCs have intrinsic defects or are disrupted by their environment is unclear.
Jimmy Massenet, Michèle Weiss-Gayet, Hina Bandukwala, Wilhelm Bouchereau, Stéphanie Gobert, Mélanie Magnan, Arnaud Hubas, Patrick Nusbaum, Isabelle Desguerre, Cyril Gitiaux, F. Jeffrey Dilworth, Bénédicte Chazaud   +11 more
doaj   +1 more source

A multiscale model for collagen alignment in wound healing [PDF]

, 2005
It is thought that collagen alignment plays a significant part in scar tissue formation during dermal wound healing. We present a multiscale model for collagen deposition and alignment during this process. We consider fibroblasts as discrete units moving
Dallon, J. C., Maini, P. K., Sherratt, J. A.   +2 more
core   +1 more source

Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies [PDF]

, 2009
In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns.
Baker, Ruth E., Maini, P. K., Schnell, S.   +2 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The transcriptome of early compensatory kidney growth reveals cell and time specific responses

iScience
Summary: Following kidney removal, the remaining kidney enlarges and increases its function. The mechanism and signals driving this compensatory kidney hypertrophy and the enlargement of its constituent kidney cells remains elusive.
Darling M. Rojas-Canales, Soon Wei Wong, Elise J. Tucker, Anthony O. Fedele, Kym McNicholas, Anne-Sophie Mehdorn, Jonathan M. Gleadle   +6 more
doaj   +1 more source

Does oxidative stress shorten telomeres in vivo? A review [PDF]

, 2017
The length of telomeres, the protective caps of chromosomes, is increasingly used as a biomarker of individual health state because it has been shown to predict chances of survival in a range of endothermic species including humans.
Reichert, Sophie, Stier, Antoine
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source